Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment

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datacite.alternateIdentifier.citationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,Vol.25,2024
datacite.alternateIdentifier.doi10.3390/ijms25105189
datacite.creatorCortez, Nicole
datacite.creatorVillegas, Cecilia
datacite.creatorBurgos, Viviana
datacite.creatorOrtiz, Leandro
datacite.creatorCabrera Pardo, Jaime R.
datacite.creatorPaz, Cristian
datacite.date2024
datacite.subject.englishchlorogenic acid
datacite.subject.englishCGA
datacite.subject.englishchemoresistance
datacite.subject.englishchemotherapy-induced toxicity
datacite.titleTherapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
dc.date.accessioned2024-09-10T18:47:14Z
dc.date.available2024-09-10T18:47:14Z
dc.description.abstractChemotherapeutic drugs are indispensable in cancer treatment, but their effectiveness is often lessened because of non-selective toxicity to healthy tissues, which triggers inflammatory pathways that are harmful to vital organs. In addition, tumors' resistance to drugs causes failures in treatment. Chlorogenic acid (5-caffeoylquinic acid, CGA), found in plants and vegetables, is promising in anticancer mechanisms. In vitro and animal studies have indicated that CGA can overcome resistance to conventional chemotherapeutics and alleviate chemotherapy-induced toxicity by scavenging free radicals effectively. This review is a summary of current information about CGA, including its natural sources, biosynthesis, metabolism, toxicology, role in combatting chemoresistance, and protective effects against chemotherapy-induced toxicity. It also emphasizes the potential of CGA as a pharmacological adjuvant in cancer treatment with drugs such as 5-fluorouracil, cisplatin, oxaliplatin, doxorubicin, regorafenib, and radiotherapy. By analyzing more than 140 papers from PubMed, Google Scholar, and SciFinder, we hope to find the therapeutic potential of CGA in improving cancer therapy.
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6012
dc.language.isoen
dc.publisherMDPI
dc.sourceINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
oaire.resourceTypeReview
uct.indizacionSCI
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