Pharmacokinetics of propofol in 10 to 15 days old foals

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dc.contributor.authorBaroni, E
dc.contributor.authorAhumada, F
dc.contributor.authorLuders, C
dc.contributor.authorSaavedra, I
dc.contributor.authorZambucetti, R
dc.date2000
dc.date.accessioned2021-04-30T17:04:08Z
dc.date.available2021-04-30T17:04:08Z
dc.description.abstractPharmacokinetic variables of propofol were studied in 8 foals. Plasma levels of propofol at different time after a single intravenous dose of 2.4 mg/kg bw, were determined by HPLC. An open two compartments model was used to evaluate plasma levels of propofol and values of t(1/2)alpha, t(1/2)beta Vd(c), Vd(ss), Vd beta, Cl-total y MRT were obtained. Propofol pharmacokinetic disposition showed a rapid distribution and removal from organic tissues, and the reported pharmacokinetic variables contribute to determine the appropriate dose to be given.
dc.identifier.citationARCHIVOS DE MEDICINA VETERINARIA,Vol.32,193-200,2000
dc.identifier.doi10.4067/S0301-732X2000000200006
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3827
dc.language.isoes
dc.publisherUNIV AUSTRAL CHILE. FAC CIENCIAS VETERINARIAS
dc.sourceARCHIVOS DE MEDICINA VETERINARIA
dc.subject.englishpharmacokinetic
dc.subject.englishpropofol
dc.subject.englishfoals
dc.titlePharmacokinetics of propofol in 10 to 15 days old foals
dc.typeReview
uct.catalogadorWOS
uct.indizacionSCI
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