Pharmacokinetics of propofol in 10 to 15 days old foals
dc.contributor.author | Baroni, E | |
dc.contributor.author | Ahumada, F | |
dc.contributor.author | Luders, C | |
dc.contributor.author | Saavedra, I | |
dc.contributor.author | Zambucetti, R | |
dc.date | 2000 | |
dc.date.accessioned | 2021-04-30T17:04:08Z | |
dc.date.available | 2021-04-30T17:04:08Z | |
dc.description.abstract | Pharmacokinetic variables of propofol were studied in 8 foals. Plasma levels of propofol at different time after a single intravenous dose of 2.4 mg/kg bw, were determined by HPLC. An open two compartments model was used to evaluate plasma levels of propofol and values of t(1/2)alpha, t(1/2)beta Vd(c), Vd(ss), Vd beta, Cl-total y MRT were obtained. Propofol pharmacokinetic disposition showed a rapid distribution and removal from organic tissues, and the reported pharmacokinetic variables contribute to determine the appropriate dose to be given. | |
dc.identifier.citation | ARCHIVOS DE MEDICINA VETERINARIA,Vol.32,193-200,2000 | |
dc.identifier.doi | 10.4067/S0301-732X2000000200006 | |
dc.identifier.uri | http://repositoriodigital.uct.cl/handle/10925/3827 | |
dc.language.iso | es | |
dc.publisher | UNIV AUSTRAL CHILE. FAC CIENCIAS VETERINARIAS | |
dc.source | ARCHIVOS DE MEDICINA VETERINARIA | |
dc.subject.english | pharmacokinetic | |
dc.subject.english | propofol | |
dc.subject.english | foals | |
dc.title | Pharmacokinetics of propofol in 10 to 15 days old foals | |
dc.type | Review | |
uct.catalogador | WOS | |
uct.indizacion | SCI |