Nanoporous Silicon Composite as Potential System for Sustained Delivery of Florfenicol Drug

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dc.contributor.authorHernández Montelongo, Jacobo
dc.contributor.authorOria, Lorena
dc.contributor.authorCardenas, Ana B.
dc.contributor.authorBenito, Noelia
dc.contributor.authorRomero Saez, Manuel
dc.contributor.authorRecio Sánchez, Gonzalo
dc.date2018
dc.date.accessioned2020-06-24T15:18:52Z
dc.date.available2020-06-24T15:18:52Z
dc.description.abstractNanostructured porous silicon (nPSi) is a nanostructured biomaterial which has received considerable attention in biomedical applications due to its biocompatibility, biodegradability, high surface area, and the ease to modify its surface chemistry. In the present work, nPSi composite microparticles are evaluated as potential drug delivery system. nPSi layers are formed by electrochemical etching of silicon wafers in hydrofluoric acid solutions. This fabrication process allows modifying the main properties of nPSi layers, including the porosity, average pore size and pore shape, by simply controlling the main parameters in the process, such as the applied current density and the electrolyte composition. nPSi microparticles are prepared from the removal and fracture by ultrasound sonication of nPSi layers. Composites are obtained from oxidized nPSi (nPSi-Ox) microparticles cascade processed with chitosan (CHI) and β-cyclodextrin (βCD) biopolymers. Samples are evaluated as drug delivery system using florfenicol (FF) as model drug, due to its economical and sanitary importance in salmon industry. Drug loaded and release kinetic tests are performed in different media: distilled water and simulated seawater. Initial data show that nPSi–βCD composites allow a mayor control in the drug time release kinetic compared to nPSi-Ox microparticles.en_US
dc.formatPDFen_US
dc.identifier.citationPhysica Status Solidi (B), Vol.255, N°10en_US
dc.identifier.doi10.1002/pssb.201700626en_US
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/2239
dc.language.isoenen_US
dc.publisherWiley-Blackwell Publishingen_US
dc.rightsObra bajo licencia Creative Commons 3.0en_US
dc.sourcePhysica Status Solidi (B)en_US
dc.subjectSilicio mesoporosoen_US
dc.subjectSilicio porosoen_US
dc.subjectflorfenicolen_US
dc.titleNanoporous Silicon Composite as Potential System for Sustained Delivery of Florfenicol Drugen_US
dc.typeArtículo de Revistaen_US
uct.catalogadormlmen_US
uct.comunidadIngenieríaen_US
uct.disciplinaMatemáticas (General)en_US
uct.facultadFacultad de Ingenieríaen_US
uct.indizacionSCOPUSen_US
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