Nanoporous silicon microparticles embedded into oxidized hyaluronic acid/adipic acid dihydrazide hydrogel for enhanced controlled drug delivery

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datacite.alternateIdentifier.citationMICROPOROUS AND MESOPOROUS MATERIALS,Vol.310,,2021
datacite.alternateIdentifier.doi10.1016/j.micromeso.2020.110634
datacite.creatorFranca, Carla Giometti
datacite.creatorPlaza, Tanya
datacite.creatorNaveas, Nelson
datacite.creatorSantana, Maria Helena Andrade
datacite.creatorManso Silvan, Miguel
datacite.creatorRecio Sánchez, Gonzalo
datacite.creatorHernandez Montelongo, Jacobo
datacite.date2021
datacite.subject.englishNanoporous silicon
datacite.subject.englishOxidized hyaluronic acid
datacite.subject.englishAdipic acid dihydrazide
datacite.subject.englishHydrogel
datacite.subject.englishMechanical resistance
datacite.subject.englishDrug delivery
datacite.titleNanoporous silicon microparticles embedded into oxidized hyaluronic acid/adipic acid dihydrazide hydrogel for enhanced controlled drug delivery
dc.date.accessioned2021-04-30T17:05:05Z
dc.date.available2021-04-30T17:05:05Z
dc.description.abstractOxidized hyaluronic acid cross-linked with adipic acid dihydrazide (oxi-HA/ADH) forms an injectable and biocompatible hydrogel suitable for treatment of musculoskeletal diseases and for drug delivery applications. that sense, nanoporous silicon (nPSi) can be combined with biopolymers, such as oxi-HA/ADH hydrogel, to display new characteristics, which are not exhibited by the individual constituents alone. Under this context, this work nPSi microparticles at concentrations from 0.1% to 1% m/v were embedded into oxi-HA/ADH hydrogel to improve its mechanical stability and enhance its control over drug release kinetics using Rose Bengal (RB) as model drug because its cytotoxic effect in different cancer cell lines and tumors has been previously reported. Our results showed, for both compressive force and stress strength tests, that oxi-HA/ADH hydrogel with 1% nPSi microparticles doubled the values of control samples. Moreover, samples of oxi-HA/ADH with nPSi microparticles improved RB release kinetics control over pure oxi-HA/ADH hydrogel. Finally, the cell viability of nPSi microparticles embedded into oxi-HA/ADH hydrogel was confirmed using fibroblasts.
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3951
dc.language.isoen
dc.publisherELSEVIER
dc.sourceMICROPOROUS AND MESOPOROUS MATERIALS
oaire.resourceTypeArticle
uct.catalogadorWOS
uct.indizacionSCI
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