Characterization of alginate from Antarctic Himantothallus grandifolius (Phaeophyceae) and preparation of polyelectrolyte complexes with chitosan

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datacite.alternateIdentifier.citationJOURNAL OF APPLIED POLYMER SCIENCE,Vol.140,2023
datacite.alternateIdentifier.doi10.1002/app.54688
datacite.creatorCandia, Carolina
datacite.creatorGallardo-Moya, Daniel
datacite.creatorGuerrero, Juan
datacite.creatorLeal, David
datacite.creatorMansilla, Andres
datacite.creatorMartinez-Gomez, Fabian
datacite.creatorMatsuhiro, Betty
datacite.creatorYanez-S, Mauricio
datacite.date2023
datacite.subject.englishalginate
datacite.subject.englishchitosan
datacite.subject.englishdrug release
datacite.subject.englishHimantothallus grandifolius
datacite.subject.englishhydrogels
datacite.subject.englishpolyelectrolyte complexes
datacite.titleCharacterization of alginate from Antarctic Himantothallus grandifolius (Phaeophyceae) and preparation of polyelectrolyte complexes with chitosan
dc.date.accessioned2024-05-27T18:26:04Z
dc.date.available2024-05-27T18:26:04Z
dc.description.abstractHydrogels are three-dimensional polymeric materials with applications in various areas such as biomedicine, tissue engineering, pollutant capture systems, and so forth. However, its application is limited due to the reproducibility of its properties. Factors such as the composition of the constituents, the type of union between the polymer chains, and the crosslinking time play a crucial role in ensuring its reproducibility. In this study, the objective is to prepare a matrix with well-defined properties that ensure controlled release processes. Treatment of Himantothallus grandifolius with Na2CO3 aqueous solution afforded in 18.9% yield alkaline extract. Hydrogels were prepared by ionic complexation of alginate from H. grandifolius, and polyguluronate enriched alginate from Desmarestia ligulata with chitosan stabilized by immersion in 0.1 M CaCl2 solution; better swelling ratio in water was found for hydrogels with low molecular weight chitosan (MW 125,000 g/mol) than those with medium molecular weight chitosan (MW450,000-500,000 g/mol). Liberation of the model drug metformin hydrochloride from alginates: chitosan complexes (3:1) at pH 1.5 was especially low for hydrogel from H. grandifolius during the first 2 h; 70% of metformin was released at pH 6.5 after 24 h. This polyelectrolyte complex constitutes a good material for potential application in biomedicine considering its cationic and anionic characteristics.
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5638
dc.language.isoen
dc.publisherWILEY
dc.sourceJOURNAL OF APPLIED POLYMER SCIENCE
oaire.resourceTypeArticle
uct.indizacionSCI
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