l-Asparaginase as the gold standard in the treatment of acute lymphoblastic leukemia: a comprehensive review
l-Asparaginase as the gold standard in the treatment of acute lymphoblastic leukemia: a comprehensive review
Authors
Tosta Perez, Maria
Herrera Belen, Lisandra
Letelier, Pablo
Calle, Yolanda
Pessoa, Adalberto
Farias, Jorge G.
Herrera Belen, Lisandra
Letelier, Pablo
Calle, Yolanda
Pessoa, Adalberto
Farias, Jorge G.
Profesor GuĆa
Authors
Date
Datos de publicaciĆ³n:
10.1007/s12032-023-02014-9
MEDICAL ONCOLOGY,Vol.40,,2023
MEDICAL ONCOLOGY,Vol.40,,2023
Tipo de recurso
Review
Keywords
Materia geogrƔfica
Collections
Abstract
l-Asparaginase is an antileukemic drug long approved for clinical use to treat childhood acute lymphoblastic leukemia, the most common cancer in this population worldwide. However, the efficacy and its use as a drug have been subject to debate due to the variety of adverse effects that patients treated with it present, as well as the prompt elimination in plasma, the need for multiple administrations, and high rates of allergic reactions. For this reason, the search for new, less immunogenic variants has long been the subject of study. This review presents the main aspects of the l-asparaginase enzyme from a structural, pharmacological, and clinical point of view, from the perspective of its use in chemotherapy protocols in conjunction with other drugs in the different treatment phases.