Toward the use of mixed microbial cultures for the biological production of adipic and levulinic acid

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datacite.alternateIdentifier.citationFRONTIERS IN MICROBIOLOGY,Vol.14,2023
datacite.alternateIdentifier.doi10.3389/fmicb.2023.1224543
datacite.creatorPinto-Ibieta, Fernanda
datacite.creatorCea, Mara
datacite.creatorSerrano, Antonio
datacite.creatorFelissia, Fernando E.
datacite.creatorArea, Maria Cristina
datacite.creatorCabrera, Francisco
datacite.creatorCiudad, Gustavo
datacite.date2023
datacite.subject.englishadipic acid
datacite.subject.englishlevulinic acid
datacite.subject.englishmixed microbial cultures (MMC)
datacite.subject.englishhemicellulose hydrolysate
datacite.subject.englishfeast and famine
datacite.titleToward the use of mixed microbial cultures for the biological production of adipic and levulinic acid
dc.date.accessioned2024-05-27T18:26:08Z
dc.date.available2024-05-27T18:26:08Z
dc.description.abstractBiological synthesis of high added-value compounds like adipic acid (AA), levulinic acid (LA), or polyhydroxybutyrate (PHB) using pure culture has been separately reported. However, pure culture requires sterile conditions and the use of specific carbon sources resulting in high operating costs. Different alternatives based on the use of mixed microbial cultures (MMC) have been explored to resolve this problem. MMC have been widely reported for the production of PHB, but scarcely reported for LA production and never for AA synthesis. This work presents a novel strategy for the co-production of AA LA, and PHB using MMC. The strategy consists in selecting an MMC producer of AA, LA and PHB from an inoculum obtained from a wastewater treatment plant, which is then subjected to the feast and famine culture strategy in a sequential batch reactor, coupled with a batch reactor step to enhance the accumulation of AA and LA. The results showed that the MMC could produce a 16 & PLUSMN; 2, 23 & PLUSMN; 1 and 5 & PLUSMN; %1 (g compound/g volatile solids) of AA, LA and PHB, respectively, using a non-fermented residual biomass rich in pentose, namely synthetic hemicellulose hydrolysate (SHH) as the carbon source. These results contribute to generating future research to better understand and optimise the biosynthesis of these compounds by MMC.
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5702
dc.language.isoen
dc.publisherFRONTIERS MEDIA SA
dc.sourceFRONTIERS IN MICROBIOLOGY
oaire.resourceTypeArticle
uct.indizacionSCI
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