Global and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile

Simple item page
dc.contributor.authorKagohara, Luciane Tsukamoto
dc.contributor.authorSchussel, Juliana L.
dc.contributor.authorSubbannayya, Tejaswini
dc.contributor.authorSahasrabuddhe, Nandini
dc.contributor.authorLebron, Cynthia
dc.contributor.authorBrait, Mariana
dc.contributor.authorMaldonado, Leonel
dc.contributor.authorValle, Blanca L.
dc.contributor.authorPirini, Francesca
dc.contributor.authorJahuira, Martha
dc.contributor.authorLopez, Jaime
dc.contributor.authorLetelier, Pablo
dc.contributor.authorBrebi Mieville, Priscilla
dc.contributor.authorIli, Carmen
dc.contributor.authorPandey, Akhilesh
dc.contributor.authorChatterjee, Aditi
dc.contributor.authorSidransky, David
dc.contributor.authorGuerrero Preston, Rafael
dc.date2015
dc.date.accessioned2021-04-30T17:06:06Z
dc.date.available2021-04-30T17:06:06Z
dc.description.abstractAim: The aim of the study was to evaluate the use of global and gene-specific DNA methylation changes as potential biomarkers for gallbladder cancer (GBC) in a cohort from Chile. Material & methods: DNA methylation was analyzed through an ELISA-based technique and quantitative methylation-specific PCR. Results: Global DNA Methylation Index (p = 0.02) and promoter methylation of SSBP2 (p = 0.01) and ESR1 (p = 0.05) were significantly different in GBC when compared with cholecystitis. Receiver curve operator analysis revealed promoter methylation of APC, CDKN2A, ESR1, PGP9.5 and SSBP2, together with the Global DNA Methylation Index, had 71% sensitivity, 95% specificity, a 0.97 area under the curve and a positive predictive value of 90%. Conclusion: Global and gene-specific DNA methylation may be useful biomarkers for GBC clinical assessment.
dc.identifier.citationFUTURE ONCOLOGY,Vol.11,233-249,2015
dc.identifier.doi10.2217/FON.14.165
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/4027
dc.language.isoen
dc.publisherFUTURE MEDICINE LTD
dc.sourceFUTURE ONCOLOGY
dc.subject.englishgallbladder cancer
dc.subject.englishglobal and gene-specific DNA methylation
dc.subject.englishmolecular biomarkers panel
dc.subject.englishtumor suppressor genes
dc.titleGlobal and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile
dc.typeArticle
uct.catalogadorWOS
uct.indizacionSCI
Files
Collections
MigraciĆ³n Web of Science