Lithium and disease modification: A systematic review and meta-analysis in Alzheimer's and Parkinson's disease

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datacite.alternateIdentifier.citationAGEING RESEARCH REVIEWS,Vol.95,2024
datacite.alternateIdentifier.doi10.1016/j.arr.2024.102231
datacite.creatorSingulani, Monique Patricio
datacite.creatorFerreira, Ana Flavia Fernandes
datacite.creatorFigueroa, Paulina Sepulveda
datacite.creatorCuyul Vasquez, Ivan
datacite.creatorTalib, Leda Leme
datacite.creatorBritto, Luiz Roberto
datacite.creatorForlenza, Orestes Vicente
datacite.date2024
datacite.subject.englishLithium
datacite.subject.englishAlzheimer 's disease
datacite.subject.englishParkinson 's disease
datacite.subject.englishprevention and treatment
datacite.subject.englishneuroprotection
datacite.titleLithium and disease modification: A systematic review and meta-analysis in Alzheimer's and Parkinson's disease
dc.date.accessioned2024-05-27T18:27:20Z
dc.date.available2024-05-27T18:27:20Z
dc.description.abstractThe role of lithium as a possible therapeutic strategy for neurodegenerative diseases has generated scientific interest. We systematically reviewed and meta-analyzed pre-clinical and clinical studies that evidenced the neuroprotective effects of lithium in Alzheimer's (AD) and Parkinson's disease (PD). We followed the PRISMA guidelines and performed the systematic literature search using PubMed, EMBASE, Web of Science, and Cochrane Library. A total of 32 articles were identified. Twenty-nine studies were performed in animal models and 3 studies were performed on human samples of AD. A total of 17 preclinical studies were included in the meta-analysis. Our analysis showed that lithium treatment has neuroprotective effects in diseases. Lithium treatment reduced amyloid-beta and tau levels and significantly improved cognitive behavior in animal models of AD. Lithium increased the tyrosine hydroxylase levels and improved motor behavior in the PD model. Despite fewer clinical studies on these aspects, we evidenced the positive effects of lithium in AD patients. This study lends further support to the idea of lithium's therapeutic potential in neurodegenerative diseases.
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5749
dc.language.isoen
dc.publisherELSEVIER IRELAND LTD
dc.sourceAGEING RESEARCH REVIEWS
oaire.resourceTypeReview
uct.indizacionSCI
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