Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress

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dc.contributor.authorFarias, Jorge G.
dc.contributor.authorMolina, Victor M.
dc.contributor.authorCarrasco, Rodrigo A.
dc.contributor.authorZepeda, Andrea B.
dc.contributor.authorFigueroa Villalobos, Elías
dc.contributor.authorLetelier, Pablo
dc.contributor.authorCastillo, Rodrigo L.
dc.date2017
dc.date.accessioned2021-04-30T17:05:08Z
dc.date.available2021-04-30T17:05:08Z
dc.description.abstractOxidative stress (OS) refers to the imbalance between the generation of reactive oxygen species (ROS) and the ability to scavenge these ROS by endogenous antioxidant systems, where ROS overwhelms the antioxidant capacity. Excessive presence of ROS results in irreversible damage to cell membranes, DNA, and other cellular structures by oxidizing lipids, proteins, and nucleic acids. Oxidative stress plays a crucial role in the pathogenesis of cardiovascular diseases related to hypoxia, cardiotoxicity and ischemia-reperfusion. Here, we describe the participation of OS in the pathophysiology of cardiovascular conditions such as myocardial infarction, anthracycline cardiotoxicity and congenital heart disease. This review focuses on the different clinical events where redox factors and OS are related to cardiovascular pathophysiology, giving to support for novel pharmacological therapies such as omega 3 fatty acids, non-selective betablockers and microRNAs.
dc.identifier.citationNUTRIENTS,Vol.9,,2017
dc.identifier.doi10.3390/nu9090966
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3994
dc.language.isoen
dc.publisherMDPI
dc.sourceNUTRIENTS
dc.subject.englishhypoxia
dc.subject.englishoxidative stress
dc.subject.englishcardiac tissue
dc.subject.englishmicroRNA
dc.subject.englishomega 3 fatty acids
dc.subject.englishcarvedilol
dc.subject.englishcongenital heart disease
dc.titleAntioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress
dc.typeReview
uct.catalogadorWOS
uct.indizacionSCI
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