Genotoxicity of copper oxide nanoparticles in Drosophila melanogaster

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datacite.alternateIdentifier.citationMUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS,Vol.791,1-11,2015
datacite.alternateIdentifier.doi10.1016/j.mrgentox.2015.07.006
datacite.creatorCarmona Ortíz, Erico
datacite.creatorInostroza Blancheteau, Claudio
datacite.creatorObando, Veroska
datacite.creatorRubio, Laura
datacite.creatorMarcos, Ricard
datacite.date2015
datacite.subject.englishComet assay
datacite.subject.englishDNA damage
datacite.subject.englishHemocytes
datacite.subject.englishMalondialdehyde
datacite.subject.englishMitotic recombination
datacite.subject.englishWing-spot test
datacite.titleGenotoxicity of copper oxide nanoparticles in Drosophila melanogaster
dc.date.accessioned2021-04-30T16:59:15Z
dc.date.available2021-04-30T16:59:15Z
dc.description.abstractCopper oxide nanoparticles (CuONPs) are used as semiconductors, catalysts, gas sensors, and antimicrobial agents. We have used the comet and wing-spot assays in Drosophila melanogaster to assess the genotoxicity of CuONPs and ionic copper (CuSO4). Lipid peroxidation analysis was also performed (Thiobarbituric Acid Assay, TBARS). In larval hemocytes, both CuONPs and CuSO4 caused significant dose-dependent increases in DNA damage (comet assay). In the wing-spot assay, an increase in the frequency of mutant spots was observed in the wings of the adults; CuONPs were more effective than was CuSO4. Both agents induced TBARS; again, CuONPs were more active than was CuSO4. The results indicate that CuONPs are genotoxic in Drosophila, and these effects may be mediated by oxidative stress. Most of the effects appear to be related to the presence of copper ions. (C) 2015 Elsevier B.V. All rights reserved.
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3781
dc.language.isoen
dc.publisherELSEVIER SCIENCE BV
dc.sourceMUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
oaire.resourceTypeArticle
uct.catalogadorWOS
uct.indizacionSCI
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