Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma

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datacite.alternateIdentifier.citationHistopathology, 74 (4), 607-597, 2019
datacite.alternateIdentifier.doi10.1111/his.13797
datacite.alternateIdentifier.issn1365-2559
datacite.creatorEspinoza, Jaime A.
datacite.creatorRiquelme, Ismael
datacite.creatorSagredo, Eduardo A.
datacite.creatorRosa, Lorena
datacite.creatorGarcía, Patricia
datacite.creatorBizama, Carolina
datacite.creatorApud-Bell, María
datacite.creatorLeal-Rojas, Pamela A.
datacite.creatorWeber, Helga L.
datacite.creatorBenavente, Felipe M.
datacite.date2019
datacite.rightsRegistro bibliográfico
datacite.subjectBiomarker
datacite.subjectCa9
datacite.subjectCldn18
datacite.subjectGallbladder Cancer
datacite.subjectMuc5b
datacite.subjectTheranostic
datacite.subjectAntigens, Neoplasm
datacite.subjectBiomarkers, Tumor
datacite.subjectCa9 Protein, Human
datacite.subjectCarbonic Anhydrase Ix
datacite.subjectClaudins
datacite.subjectCldn18 Protein, Human
datacite.subjectMucin-5b
datacite.subjectCarbonate Dehydratase Ix
datacite.subjectClaudin 18
datacite.subjectMessenger Rna
datacite.subjectMucin 5b
datacite.subjectProtein P53
datacite.subjectProteome
datacite.subjectTranscription Factor Cdx2
datacite.subjectTranscriptome
datacite.subjectTumor Marker
datacite.subjectCa9 Protein, Human
datacite.subjectClaudin
datacite.subjectCldn18 Protein, Human
datacite.subjectTumor Antigen
datacite.subjectAdult
datacite.subjectAdvanced Cancer
datacite.subjectAged
datacite.subjectArticle
datacite.subjectBile Duct Carcinoma
datacite.subjectCancer Growth
datacite.subjectCancer Patient
datacite.subjectCarcinogenesis
datacite.subjectChronic Cholecystitis
datacite.subjectClinical Feature
datacite.subjectCohort Analysis
datacite.subjectDysplasia
datacite.subjectFemale
datacite.subjectGallbladder Carcinoma
datacite.subjectGallbladder Epithelium
datacite.subjectHuman
datacite.subjectHuman Cell
datacite.subjectHuman Tissue
datacite.subjectImmunohistochemistry
datacite.subjectMajor Clinical Study
datacite.subjectMale
datacite.subjectMolecular Pathology
datacite.subjectMrna Expression Level
datacite.subjectPriority Journal
datacite.subjectProtein Expression Level
datacite.subjectTissue Microarray
datacite.subjectBiosynthesis
datacite.subjectGallbladder Tumor
datacite.subjectMiddle Aged
datacite.subjectPathology
datacite.subjectProcedures
datacite.subjectTheranostic Nanomedicine
datacite.subjectAdult
datacite.subjectAged
datacite.subjectAntigens, Neoplasm
datacite.subjectBiomarkers, Tumor
datacite.subjectCarbonic Anhydrase Ix
datacite.subjectClaudins
datacite.subjectFemale
datacite.subjectGallbladder Neoplasms
datacite.subjectHumans
datacite.subjectMale
datacite.subjectMiddle Aged
datacite.subjectMucin-5b
datacite.subjectTheranostic Nanomedicine
datacite.titleMucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma
dc.date.accessioned2025-10-06T14:21:54Z
dc.date.available2025-10-06T14:21:54Z
dc.description.abstractAims: Gallbladder cancer (GBC) is an aggressive tumour that is usually diagnosed at advanced stages and is characterised by a poor prognosis. Using public data of normal human tissues, we found that mRNA and protein levels of mucin 5B (MUC5B) and carbonic anhydrase 9 (CA9) were highly increased in gallbladder tissues. In addition, previous evidence has shown that claudin 18 (CLDN18) protein expression is higher in GBC. The aim of this study was to perform an analysis of these cell surface proteins during the histological progression of GBC in order to identify their theranostic potential. Methods and results: MUC5B expression, CA9 expression and CLDN18 expression were examined by immunohistochemistry in a series of 179 chronic cholecystitis (including 16 metaplastic tissues), 15 dysplasia and 217 GBC samples by the use of tissue microarray analysis. A composite staining score was calculated from staining intensity and percentage of positive cells. Immunohistochemical analysis showed high expression of MUC5B and CA9 among normal epithelium, metaplastic tissues, and dysplastic tissues. However, expression of both proteins was observed in roughly 50% of GBC samples. In contrast, CLDN18 was absent in normal epithelium, but its expression was higher in metaplastic cells. Among GBC cases, approximately half showed high CLDN18 expression. No associations were found between MUC5B, CA9 and CLDN18 expression and any clinicopathological features. Conclusions: CLDN18 is a new metaplasia marker in gallbladder tissues, and is conserved in approximately half of GBC cases. MUC5B and CA9 are highly conserved during GBC histological progression. The three markers are potential theranostic markers, in particular CA9 and CLDN18, for which there are already targeted therapies available. © 2019 Elsevier B.V., All rights reserved.
dc.description.ia_keywordexpression, cldn, tissues, gallbladder, normal, were, theranostic
dc.identifier.issn0309-0167
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6857
dc.language.isoen
dc.publisherWiley
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceHistopathology
dc.subject.ia_odsODS 1: Fin de la pobreza
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Biológicas
dc.subject.ia_oecd3nBiología General
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2019
oaire.citationEndPage607
oaire.citationIssue4
oaire.citationStartPage597
oaire.citationTitleHistopathology
oaire.citationVolume74
oaire.fundingReferenceANID FONDECYT 1170893, 11130515, 3140308, 11180987, 3140426
oaire.fundingReferenceCancerfonden CAN 2015/739 (Suecia)
oaire.licenseConditionCopyright © Elsevier Ltd, 2025
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
uct.catalogadorjvu
uct.comunidadCiencias de la Saluden_US
uct.departamentoDepartamento de Procesos Diagnósticos y Evaluación
uct.facultadFacultad de Ciencias de la Salud
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed
uct.indizacionEmbase
uct.indizacionMEDLINE
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