Optimisation of the biological production of levulinic acid in a mixed microbial culture fed with synthetic grape pomace

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datacite.alternateIdentifier.citationFrontiers in Bioengineering and Biotechnology, 12, 2024
datacite.alternateIdentifier.doi10.3389/fbioe.2024.1398110
datacite.alternateIdentifier.issn2296-4185
datacite.creatorCorrea-Galeote, David
datacite.creatorSerrano, Antonio
datacite.creatorCiudad, Gustavo A.
datacite.creatorPinto-Ibieta, Fernanda
datacite.date2024
datacite.rightsAcceso abierto
datacite.subjectBiological Production
datacite.subjectFeast And Famine
datacite.subjectGrape Pomace Hydrolysate
datacite.subjectMixed Microbial Culture
datacite.subjectOrganic Loading Rate
datacite.subjectPolyhydroxyalkanoates
datacite.subjectFood Supply
datacite.subjectOrganic Acids
datacite.subjectAcid Accumulations
datacite.subjectBiological Production
datacite.subjectCarbon-nitrogen Ratio
datacite.subjectFeast And Famine
datacite.subjectGrape Pomace
datacite.subjectGrape Pomace Hydrolysate
datacite.subjectLevulinic Acid
datacite.subjectMixed Microbial Culture
datacite.subjectOrganic Loading Rates
datacite.subjectPolyhydroxyalkanoates
datacite.subjectSubstrates
datacite.titleOptimisation of the biological production of levulinic acid in a mixed microbial culture fed with synthetic grape pomace
dc.contributor.authorPINTO IBIETA, FERNANDA EMILIA
dc.date.accessioned2025-10-06T14:21:52Z
dc.date.available2025-10-06T14:21:52Z
dc.description.abstractLevulinic acid (LA) is a polymer with a vast industrial application range and can be co-produced as a minor by-product during the biological production of polyhydroxyalkanoates (PHA). However, the influence of key parameters as tools for favouring the production of LA over PHA is still unclear. In this study, we investigated how several critical operational conditions, i.e., carbon-nitrogen ratio (C/N), organic loading rate (OLR) and airflow, can be optimised to favour LA accumulation over PHA production by a mixed microbial culture (MMC), using synthetic grape pomace (GP) hydrolysate as the substrate. The results showed that it was possible to direct the MMC towards LA accumulation instead of PHA. The maximum LA yield was 2.7 ± 0.2 g LA/(L·d) using a C/N of 35, an airflow of 5 L/min and an OLR of 4 g sCOD/(L·d). The OLR and, to a lesser extent, the C/N ratio were the main factors significantly and positively correlated with the biological synthesis of LA. © 2024 Elsevier B.V., All rights reserved.
dc.description.ia_keywordproduction, biological, levulinic, acid, over, ratio, airflow
dc.formatPDF
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6845
dc.language.isoen
dc.publisherFrontiers Media
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceFrontiers in Bioengineering and Biotechnology
dc.subject.ia_odsODS 13: Acción por el clima
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Físicas
dc.subject.ia_oecd3nQuímica
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2024
oaire.citationTitleFrontiers in Bioengineering and Biotechnology
oaire.citationVolume12
oaire.fundingReferenceANID FONDECYT 3210626 (Postdoctorado)
oaire.fundingReferenceJunta de Andalucía EMERGIA20_00114
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
relation.isAuthorOfPublication222c7a9b-189a-4a82-8d38-89ca7765bd44
relation.isAuthorOfPublication.latestForDiscovery222c7a9b-189a-4a82-8d38-89ca7765bd44
uct.catalogadorjvu
uct.comunidadIngenieríaen_US
uct.departamentoDepartamento Procesos Industriales
uct.facultadFacultad de Ingeniería
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionSCOPUS
uct.indizacionWOS
uct.indizacionDOAJ
uct.indizacionPubMed
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