Oxidized hyaluronic acid/adipic acid dihydrazide hydrogel as cell microcarriers for tissue regeneration applications

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datacite.alternateIdentifier.citationE-Polymers, 22 (1), 958-949, 2022
datacite.alternateIdentifier.doi10.1515/epoly-2022-0086
datacite.alternateIdentifier.issn2197-4586
datacite.creatorFranca, Carla Giometti
datacite.creatorLeme, Krissia Caroline
datacite.creatorMalheiros Luzo, Angela Cristina
datacite.creatorHernandez-Montelongo, Jacobo
datacite.creatorAndrade Santana, Maria Helena
datacite.date2022
datacite.rightsAcceso abierto
datacite.subjectoxidized hyaluronic acid
datacite.subjectadipic dihydrazide
datacite.subjecthydrogel microcarriers
datacite.subjectinjectability
datacite.subjecttissue engineering
datacite.titleOxidized hyaluronic acid/adipic acid dihydrazide hydrogel as cell microcarriers for tissue regeneration applications
dc.contributor.authorHERNANDEZ MONTELONGO, JESUS JACOBO
dc.date.accessioned2025-10-06T14:21:49Z
dc.date.available2025-10-06T14:21:49Z
dc.description.abstractHyaluronic acid (HA) is a biopolymer present in various human tissues, whose degradation causes tissue damage and diseases. The oxidized hyaluronic acid/adipic acid dihydrazide (oxi-HA/ADH) hydrogels have attracted attention due to their advantages such as thermosensitivity, injectability, in situ gelation, and sterilization. However, studies are still scarce in the literature as microcarriers. In that sense, this work is a study of oxi-HA/ADH microparticles of 215.6 & PLUSMN; 2.7 mu m obtained by high-speed shearing (18,000 rpm at pH 7) as cell microcarriers. Results showed that BALB/c 3T3 fibroblasts and adipose mesenchymal stem cells (h-AdMSC) cultured on the oxi-HA/ADH microcarriers presented a higher growth of both cells in comparison with the hydrogel. Moreover, the extrusion force of oxi-HA/ADH microparticles was reduced by 35% and 55% with the addition of 25% and 75% HA fluid, respectively, thus improving its injectability. These results showed that oxi-HA/ADH microcarriers can be a potential injectable biopolymer for tissue regeneration applications.
dc.description.ia_keywordacid, microcarriers, hyaluronic, tissue, biopolymer, oxidized, adipic
dc.formatPDF
dc.identifier.issn1618-7229
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6821
dc.language.isoen
dc.publisherDe Gruyter
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceE-Polymers
dc.subject.ia_odsODS 8: Trabajo decente y crecimiento económico
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Biológicas
dc.subject.ia_oecd3nBiología General
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2022
oaire.citationEndPage958
oaire.citationIssue1
oaire.citationStartPage949
oaire.citationTitleE-Polymers
oaire.citationVolume22
oaire.fundingReferenceCNPq Brasil
oaire.fundingReferenceFAPESP 140924/2017-5
oaire.fundingReferenceANID FONDECYT 2016/10132-0, 11180395
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
relation.isAuthorOfPublicationd1ebb975-fdac-4b8f-9131-a735b8c04d80
relation.isAuthorOfPublication.latestForDiscoveryd1ebb975-fdac-4b8f-9131-a735b8c04d80
uct.catalogadorjvu
uct.comunidadIngenieríaen_US
uct.departamentoDepartamento de Ciencias Matemáticas y Físicas
uct.facultadFacultad de Ingeniería
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionSCOPUS
uct.indizacionWOS
uct.indizacionDOAJ
uct.indizacionGoogle Scholar
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