Cost Function Analysis Applied to Different Kinetic Release Models of Arrabidaea chica Verlot Extract from Chitosan/Alginate Membranes

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datacite.alternateIdentifier.citationPolymers, 14 (6), 2022
datacite.alternateIdentifier.doi10.3390/polym14061109
datacite.creatorConcha, Luis
datacite.creatorResende Pires, Ana Luiza
datacite.creatorMoraes, Angela Maria
datacite.creatorMas-Hernandez, Elizabeth
datacite.creatorBerres, Stefan
datacite.creatorHernandez-Montelongo, Jacobo
datacite.date2022
datacite.rightsAcceso abierto
datacite.subjectcost function
datacite.subjectcontrolled release
datacite.subjectArrabidae chica Verlot
datacite.subjectchitosan
datacite.subjectalginate membranes
datacite.titleCost Function Analysis Applied to Different Kinetic Release Models of Arrabidaea chica Verlot Extract from Chitosan/Alginate Membranes
dc.contributor.authorHERNANDEZ MONTELONGO, JESUS JACOBO
dc.description.abstractThis work focuses on the mathematical analysis of the controlled release of a standardized extract of A. chica from chitosan/alginate (C/A) membranes, which can be used for the treatment of skin lesions. Four different types of C/A membranes were tested: a dense membrane (CA), a dense and flexible membrane (CAS), a porous membrane (CAP) and a porous and flexible membrane (CAPS). The Arrabidae chica extract release profiles were obtained experimentally in vitro using PBS at 37 degrees C and pH 7. Experimental data of release kinetics were analyzed using five classical models from the literature: Zero Order, First Order, Higuchi, Korsmeyer-Peppas and Weibull functions. Results for the Korsmeyer-Peppas model showed that the release of A. chica extract from four membrane formulations was by a diffusion through a partially swollen matrix and through a water filled network mesh; however, the Weibull model suggested that non-porous membranes (CA and CAS) had fractal geometry and that porous membranes (CAP and CAPS) have highly disorganized structures. Nevertheless, by applying an explicit optimization method that employs a cost function to determine the model parameters that best fit to experimental data, the results indicated that the Weibull model showed the best simulation for the release profiles from the four membranes: CA, CAS and CAP presented Fickian diffusion through a polymeric matrix of fractal geometry, and only the CAPS membrane showed a highly disordered matrix. The use of this cost function optimization had the significant advantage of higher fitting sensitivity.
dc.description.ia_keywordrelease, membranes, membrane, extract, chica, porous, model
dc.formatPDF
dc.identifier.issn2073-4360
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/4541
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourcePolymers
dc.subject.ia_odsODS 6: Agua limpia y saneamiento
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nMatemáticas y Estadística
dc.subject.ia_oecd3nMatemáticas
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2022
oaire.citationIssue6
oaire.citationTitlePolymers
oaire.citationVolume14
oaire.fundingReferenceANID FONDECYT 11180395 (Regular)
oaire.fundingReferenceCNPq Brasil 307829/2018-9, 152053/2014-0
oaire.fundingReferenceCAPES Brasil 001
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
relation.isAuthorOfPublicationd1ebb975-fdac-4b8f-9131-a735b8c04d80
relation.isAuthorOfPublication.latestForDiscoveryd1ebb975-fdac-4b8f-9131-a735b8c04d80
uct.catalogadorjvu
uct.comunidadIngenieríaen_US
uct.departamentoDepartamento de Ciencias Matemáticas y Físicas
uct.facultadFacultad de Ingeniería
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed Central (PMC)
uct.indizacionChemical Abstracts Service (CAS)
uct.indizacionEi Compendex
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