Role of microRNA Shuttled in Small Extracellular Vesicles Derived From Mesenchymal Stem/Stromal Cells for Osteoarticular Disease Treatment

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datacite.alternateIdentifier.citationFrontiers in Immunology, 12, 2021
datacite.alternateIdentifier.doi10.3389/fimmu.2021.768771
datacite.alternateIdentifier.issn1664-3224
datacite.creatorLara-Barba, Eliana
datacite.creatorAraya, María Jesús
datacite.creatorHill, Charlotte Nicole
datacite.creatorBustamante-Barrientos, Felipe A.
datacite.creatorOrtloff, Alexander R.
datacite.creatorGarcía, Cynthia
datacite.creatorGalvez-Jiron, Felipe
datacite.creatorPradenas, Carolina
datacite.creatorLuque-Campos, Noymar
datacite.creatorMaita, Gabriela
datacite.date2021
datacite.rightsAcceso abierto
datacite.subjectMesenchymal Stem Cells
datacite.subjectMicrorna
datacite.subjectOsteoarthritis
datacite.subjectRheumatoid Arthritis
datacite.subjectSmall Extracellular Vesicles
datacite.subject5' Nucleotidase
datacite.subjectMicrornas
datacite.subjectTransforming Growth Factor Beta
datacite.subject5' Nucleotidase
datacite.subjectBone Morphogenetic Protein 2
datacite.subjectBotulinum Toxin
datacite.subjectCd11b Antigen
datacite.subjectCd14 Antigen
datacite.subjectCd19 Antigen
datacite.subjectCd34 Antigen
datacite.subjectCd45ra Antigen
datacite.subjectEndoglin
datacite.subjectMicrorna
datacite.subjectThy 1 Membrane Glycoprotein
datacite.subjectTransforming Growth Factor Beta
datacite.subjectAdaptive Immunity
datacite.subjectArthroscopic Debridement
datacite.subjectCarcinogenesis
datacite.subjectCell Differentiation
datacite.subjectChondrogenesis
datacite.subjectCytokine Production
datacite.subjectExosome
datacite.subjectExtracellular Matrix
datacite.subjectGene Expression
datacite.subjectGene Expression Regulation
datacite.subjectGenetic Engineering
datacite.subjectImmunomodulation
datacite.subjectInflammation
datacite.subjectMembrane Microparticle
datacite.subjectMesenchymal Stem Cell
datacite.subjectMultivesicular Body
datacite.subjectNuclear Reprogramming
datacite.subjectOsteoarthropathy
datacite.subjectPhagocytosis
datacite.subjectQuality Of Life
datacite.subjectRegulatory B Lymphocyte
datacite.subjectRegulatory T Lymphocyte
datacite.subjectReview
datacite.subjectRheumatoid Arthritis
datacite.subjectSignal Transduction
datacite.subjectStroma Cell
datacite.subjectTissue Differentiation
datacite.subjectHuman
datacite.subjectMesenchymal Stem Cell Transplantation
datacite.subjectOsteoarthritis
datacite.subjectPhysiology
datacite.subjectArthritis, Rheumatoid
datacite.subjectExtracellular Vesicles
datacite.subjectHumans
datacite.subjectMesenchymal Stem Cell Transplantation
datacite.subjectMicrornas
datacite.subjectOsteoarthritis
datacite.subjectTransforming Growth Factor Beta
datacite.titleRole of microRNA Shuttled in Small Extracellular Vesicles Derived From Mesenchymal Stem/Stromal Cells for Osteoarticular Disease Treatment
dc.contributor.authorORTLOFF TRAUTMANN, ALEXANDER
dc.description.abstractOsteoarticular diseases (OD), such as rheumatoid arthritis (RA) and osteoarthritis (OA) are chronic autoimmune/inflammatory and age-related diseases that affect the joints and other organs for which the current therapies are not effective. Cell therapy using mesenchymal stem/stromal cells (MSCs) is an alternative treatment due to their immunomodulatory and tissue differentiation capacity. Several experimental studies in numerous diseases have demonstrated the MSCs therapeutic effects. However, MSCs have shown heterogeneity, instability of stemness and differentiation capacities, limited homing ability, and various adverse responses such as abnormal differentiation and tumor formation. Recently, acellular therapy based on MSC secreted factors has raised the attention of several studies. It has been shown that molecules embedded in extracellular vesicles (EVs) derived from MSCs, particularly those from the small fraction enriched in exosomes (sEVs), effectively mimic their impact in target cells. The biological effects of sEVs critically depend on their cargo, where sEVs-embedded microRNAs (miRNAs) are particularly relevant due to their crucial role in gene expression regulation. Therefore, in this review, we will focus on the effect of sEVs derived from MSCs and their miRNA cargo on target cells associated with the pathology of RA and OA and their potential therapeutic impact. © 2021 Elsevier B.V., All rights reserved.
dc.description.ia_keywordmscs, cells, sevs, diseases, differentiation, derived, osteoarticular
dc.formatPDF
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/4453
dc.language.isoen
dc.publisherFrontiers Media
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceFrontiers in Immunology
dc.subject.ia_odsODS 3: Salud y bienestar
dc.subject.ia_oecd1nCiencias Médicas y de la Salud
dc.subject.ia_oecd2nMedicina Clínica
dc.subject.ia_oecd3nMedicina Clínica
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2021
oaire.citationTitleFrontiers in Immunology
oaire.citationVolume12
oaire.fundingReferenceANID FONDECYT 1211353 (Regular)
oaire.fundingReferenceANR METAB-OA (ANR-20-CE18-0014)
oaire.fundingReferencePRI-mitoMir
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo de revisión
oaire.resourceType.enReview
relation.isAuthorOfPublication798755f1-1bb9-449a-b2e2-d4bbe38ca016
relation.isAuthorOfPublication.latestForDiscovery798755f1-1bb9-449a-b2e2-d4bbe38ca016
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Veterinarias y Salud Pública
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionSCOPUS
uct.indizacionWOS
uct.indizacionDOAJ
uct.indizacionPubMed
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