Epothilones as Natural Compounds for Novel Anticancer Drugs Development

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datacite.alternateIdentifier.citationInternational Journal of Molecular Sciences, 24 (7), 2023
datacite.alternateIdentifier.doi10.3390/ijms24076063
datacite.alternateIdentifier.issn1422-0067
datacite.creatorVillegas, Cecilia
datacite.creatorGonzález-Chavarría, Iván
datacite.creatorBurgos, Viviana
datacite.creatorIturra-Beiza, Héctor
datacite.creatorUlrich, Henning
datacite.creatorPaz, Cristian
datacite.date2023
datacite.rightsAcceso abierto
datacite.subjectAnticancer Agents
datacite.subjectClinical Trials
datacite.subjectCytotoxicity
datacite.subjectEpothilone Derivates
datacite.subjectEpothilones
datacite.subjectRefractory Cancer
datacite.subjectTaxanes
datacite.subjectCapecitabine
datacite.subjectEpothilone A
datacite.subjectEpothilone B
datacite.subjectIxabepilone
datacite.subjectPaclitaxel
datacite.subjectAntineoplastic Agents
datacite.subjectCapecitabine
datacite.subjectEpothilones
datacite.subjectIxabepilone
datacite.subjectPaclitaxel
datacite.subjectTubulin Modulators
datacite.subjectAntineoplastic Agent
datacite.subjectCapecitabine
datacite.subjectEpothilone A
datacite.subjectEpothilone B
datacite.subjectEpothilone Derivative
datacite.subjectIxabepilone
datacite.subjectPaclitaxel
datacite.subjectUnclassified Drug
datacite.subjectUtidelone
datacite.subjectTubulin Modulator
datacite.subjectAntineoplastic Activity
datacite.subjectApoptosis
datacite.subjectCancer Cell Line
datacite.subjectCancer Patient
datacite.subjectClinical Practice
datacite.subjectDrug Cytotoxicity
datacite.subjectDrug Design
datacite.subjectDrug Mechanism
datacite.subjectDrug Safety
datacite.subjectDrug Synthesis
datacite.subjectHek293 Cell Line
datacite.subjectHuman
datacite.subjectMcf-7 Cell Line
datacite.subjectMda-mb-435 Cell Line
datacite.subjectMes Sa Dx Cell Line
datacite.subjectMes-sa Cell Line
datacite.subjectMicrotubule Assembly
datacite.subjectNci-adr-res Cell Line
datacite.subjectNonhuman
datacite.subjectOvcar-8 Cell Line
datacite.subjectPhase 2 Clinical Trial (topic)
datacite.subjectPhase 3 Clinical Trial (topic)
datacite.subjectPreclinical Study
datacite.subjectReview
datacite.subjectSnb-75 Cell Line
datacite.subjectTriple Negative Breast Cancer
datacite.subjectTumor Resistance
datacite.subjectNeoplasm
datacite.subjectAntineoplastic Agents
datacite.subjectCapecitabine
datacite.subjectEpothilones
datacite.subjectHumans
datacite.subjectNeoplasms
datacite.subjectPaclitaxel
datacite.subjectTubulin Modulators
datacite.titleEpothilones as Natural Compounds for Novel Anticancer Drugs Development
dc.description.abstractEpothilone is a natural 16-membered macrolide cytotoxic compound produced by the metabolism of the cellulose-degrading myxobacterium Sorangium cellulosum. This review summarizes results in the study of epothilones against cancer with preclinical results and clinical studies from 2010 2022. Epothilone have mechanisms of action similar to paclitaxel by inducing tubulin polymerization and apoptosis with low susceptibility to tumor resistance mechanisms. It is active against refractory tumors, being superior to paclitaxel in many respects. Since the discovery of epothilones, several derivatives have been synthesized, and most of them have failed in Phases II and III in clinical trials; however, ixabepilone and utidelone are currently used in clinical practice. There is robust evidence that triple-negative breast cancer (TNBC) treatment improves using ixabepilone plus capecitabine or utidelone in combination with capecitabine. In recent years innovative synthetic strategies resulted in the synthesis of new epothilone derivatives with improved activity against refractory tumors with better activities when compared to ixabepilone or taxol. These compounds together with specific delivery mechanisms could be developed in anti-cancer drugs. © 2023 Elsevier B.V., All rights reserved.
dc.description.ia_keywordepothilone, epothilones, against, cancer, clinical, mechanisms, ixabepilone
dc.formatPDF
dc.identifier.issn1661-6596
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5287
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourceInternational Journal of Molecular Sciences
dc.subject.ia_oecd1nCiencias Médicas y de la Salud
dc.subject.ia_oecd2nMedicina Clínica
dc.subject.ia_oecd3nMedicina Clínica
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2023
oaire.citationIssue7
oaire.citationTitleInternational Journal of Molecular Sciences
oaire.citationVolume24
oaire.fundingReferenceFAPESP 2018/07366-4
oaire.fundingReferenceFAPESP-CONICYT 201808426-0
oaire.fundingReferenceANID FONDECYT 1220831, 11181105 (Regular)
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo de revisión
oaire.resourceType.enReview
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Biológicas y Químicas
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed Central (PMC)
uct.indizacionChemical Abstracts Service (CAS)
uct.indizacionMEDLINE
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