Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities

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datacite.alternateIdentifier.citationAntioxidants, 12 (8), 2023
datacite.alternateIdentifier.doi10.3390/antiox12081500
datacite.alternateIdentifier.issn2076-3921
datacite.creatorPérez, Rebeca
datacite.creatorBurgos, Viviana
datacite.creatorMarin, Victor
datacite.creatorCamins, Antoni
datacite.creatorOlloquequi, Jordi
datacite.creatorGonzález-Chavarría, Iván
datacite.creatorUlrich, Henning
datacite.creatorWyneken, Ursula
datacite.creatorLuarte, Alejandro
datacite.creatorOrtíz, Leandro
datacite.date2023
datacite.rightsAcceso abierto
datacite.subjectAnti-inflammatory
datacite.subjectAntioxidant
datacite.subjectCaffeic Acid Phenethyl Ester
datacite.subjectCape Derivatives
datacite.subjectNeuroprotection
datacite.subjectNf-?b
datacite.subjectNrf2
datacite.titleCaffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities
dc.date.accessioned2025-10-06T14:21:41Z
dc.date.available2025-10-06T14:21:41Z
dc.description.abstractNeurodegenerative disorders are characterized by a progressive process of degeneration and neuronal death, where oxidative stress and neuroinflammation are key factors that contribute to the progression of these diseases. Therefore, two major pathways involved in these pathologies have been proposed as relevant therapeutic targets: The nuclear transcription factor erythroid 2 (Nrf2), which responds to oxidative stress with cytoprotecting activity; and the nuclear factor NF-?B pathway, which is highly related to the neuroinflammatory process by promoting cytokine expression. Caffeic acid phenethyl ester (CAPE) is a phenylpropanoid naturally found in propolis that shows important biological activities, including neuroprotective activity by modulating the Nrf2 and NF-?B pathways, promoting antioxidant enzyme expression and inhibition of proinflammatory cytokine expression. Its simple chemical structure has inspired the synthesis of many derivatives, with aliphatic and/or aromatic moieties, some of which have improved the biological properties. Moreover, new drug delivery systems increase the bioavailability of these compounds in vivo, allowing its transcytosis through the blood-brain barrier, thus protecting brain cells from the increased inflammatory status associated to neurodegenerative and psychiatric disorders. This review summarizes the biosynthesis and chemical synthesis of CAPE derivatives, their miscellaneous activities, and relevant studies (from 2010 to 2023), addressing their neuroprotective activity in vitro and in vivo. © 2023 Elsevier B.V., All rights reserved.
dc.description.ia_keywordthese, activity, expression, cape, activities, neuroprotective, derivatives
dc.formatPDF
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6738
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourceAntioxidants
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Físicas
dc.subject.ia_oecd3nQuímica
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2023
oaire.citationIssue8
oaire.citationTitleAntioxidants
oaire.citationVolume12
oaire.fundingReferenceANID FONDECYT 1220831
oaire.fundingReferenceFAPESP 2018/07366-4
oaire.fundingReferenceANID BASAL FB210024
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo de revisión
oaire.resourceType.enReview
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Biológicas y Químicas
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed
uct.indizacionDOAJ
uct.indizacionScimago
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