Lithium and disease modification: A systematic review and meta-analysis in Alzheimer's and Parkinson's disease

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datacite.alternateIdentifier.citationAgeing Research Reviews, 95, 2024
datacite.alternateIdentifier.doi10.1016/j.arr.2024.102231
datacite.alternateIdentifier.issn1872-9649
datacite.creatorSingulani, Monique Patricio
datacite.creatorFerreira, Ana Flávia Fernandes
datacite.creatorFigueroa, Paulina Sepúlveda
datacite.creatorCuyul-Vásquez, Iván
datacite.creatorTalib, Leda Leme
datacite.creatorBritto, Luiz Roberto Giorgetti
datacite.creatorForlenza, Orestes Vicente
datacite.date2024
datacite.rightsRegistro bibliográfico
datacite.subjectAlzheimer's Disease
datacite.subjectLithium
datacite.subjectNeuroprotection
datacite.subjectParkinson's Disease
datacite.subjectPrevention And Treatment
datacite.subjectAluminum Chloride
datacite.subjectAmyloid Beta Protein
datacite.subjectDermatan Sulfate
datacite.subjectGalactose
datacite.subjectGluconic Acid
datacite.subjectLithium
datacite.subjectLithium Carbonate
datacite.subjectLithium Chloride
datacite.subjectLithium Citrate
datacite.subjectOkadaic Acid
datacite.subjectStreptozocin
datacite.subjectTyrosine 3 Monooxygenase
datacite.subjectLithium
datacite.subjectLithium Compounds
datacite.subjectNeuroprotective Agents
datacite.subjectAluminum Chloride
datacite.subjectAmyloid Beta Protein
datacite.subjectAmyloid Beta Protein[25-35]
datacite.subjectDermatan Sulfate
datacite.subjectGalactose
datacite.subjectGluconic Acid
datacite.subjectImmunotoxin
datacite.subjectImmunotoxin 192 Immunoglobulin Saporin
datacite.subjectLithium
datacite.subjectLithium Benzoate
datacite.subjectLithium Carbonate
datacite.subjectLithium Chloride
datacite.subjectLithium Citrate
datacite.subjectLithium Pyrroloquinoline
datacite.subjectLithium Salicylate Proline
datacite.subjectNeuroprotective Agent
datacite.subjectOkadaic Acid
datacite.subjectStreptozocin
datacite.subjectTau Protein
datacite.subjectTyrosine 3 Monooxygenase
datacite.subjectUnclassified Drug
datacite.subjectLithium Derivative
datacite.subjectAged
datacite.subjectAlzheimer Disease
datacite.subjectCochrane Library
datacite.subjectCognition
datacite.subjectEmbase
datacite.subjectFemale
datacite.subjectHuman
datacite.subjectLocomotion
datacite.subjectMale
datacite.subjectMedline
datacite.subjectMeta Analysis
datacite.subjectNeuroprotection
datacite.subjectNonhuman
datacite.subjectParkinson Disease
datacite.subjectPreclinical Study
datacite.subjectPreferred Reporting Items For Systematic Reviews And Meta-analyses
datacite.subjectProtein Blood Level
datacite.subjectReview
datacite.subjectSystematic Review
datacite.subjectWeb Of Science
datacite.subjectAnimal
datacite.subjectDegenerative Disease
datacite.subjectAlzheimer Disease
datacite.subjectAnimals
datacite.subjectHumans
datacite.subjectLithium
datacite.subjectLithium Compounds
datacite.subjectNeurodegenerative Diseases
datacite.subjectNeuroprotective Agents
datacite.subjectParkinson Disease
datacite.titleLithium and disease modification: A systematic review and meta-analysis in Alzheimer's and Parkinson's disease
dc.date.accessioned2025-10-06T14:21:37Z
dc.date.available2025-10-06T14:21:37Z
dc.description.abstractThe role of lithium as a possible therapeutic strategy for neurodegenerative diseases has generated scientific interest. We systematically reviewed and meta-analyzed pre-clinical and clinical studies that evidenced the neuroprotective effects of lithium in Alzheimer's (AD) and Parkinson's disease (PD). We followed the PRISMA guidelines and performed the systematic literature search using PubMed, EMBASE, Web of Science, and Cochrane Library. A total of 32 articles were identified. Twenty-nine studies were performed in animal models and 3 studies were performed on human samples of AD. A total of 17 preclinical studies were included in the meta-analysis. Our analysis showed that lithium treatment has neuroprotective effects in diseases. Lithium treatment reduced amyloid-? and tau levels and significantly improved cognitive behavior in animal models of AD. Lithium increased the tyrosine hydroxylase levels and improved motor behavior in the PD model. Despite fewer clinical studies on these aspects, we evidenced the positive effects of lithium in AD patients. This study lends further support to the idea of lithium's therapeutic potential in neurodegenerative diseases. © 2024 Elsevier B.V., All rights reserved.
dc.description.ia_keywordlithium, were, diseases, meta, clinical, effects, disease
dc.identifier.issn1568-1637
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6704
dc.language.isoen
dc.publisherElsevier BV
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceAgeing Research Reviews
dc.subject.ia_odsODS 3: Salud y bienestar
dc.subject.ia_oecd1nCiencias Médicas y de la Salud
dc.subject.ia_oecd2nMedicina Clínica
dc.subject.ia_oecd3nMedicina Clínica
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2024
oaire.citationTitleAgeing Research Reviews
oaire.citationVolume95
oaire.fundingReferenceCNPq 303006/2018-8, 167176/2023-4
oaire.fundingReferenceCAPES 001, 88887.514714/2020-00
oaire.fundingReferenceFAPESP 2021/06378-1, 2018/07366-4, 2020/02109-3
oaire.fundingReferenceANID FONDECYT 11240905 (Regular)
oaire.fundingReferenceINBioN 465412/2014-9, 2014/50873-3
oaire.licenseConditionCopyright © Elsevier Inc, 2024
oaire.resourceTypeArtículo de revisión
oaire.resourceType.enReview
uct.catalogadorjvu
uct.comunidadCiencias de la Saluden_US
uct.departamentoDepartamento de Procesos Terapéuticos
uct.facultadFacultad de Ciencias de la Salud
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionScimago
uct.indizacionPubMed
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