Toward the use of mixed microbial cultures for the biological production of adipic and levulinic acid

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datacite.alternateIdentifier.citationFrontiers in Microbiology, 14, 2023
datacite.alternateIdentifier.doi10.3389/fmicb.2023.1224543
datacite.alternateIdentifier.issn1664-302X
datacite.creatorPinto-Ibieta, Fernanda
datacite.creatorCea, Mara
datacite.creatorSerrano, Antonio
datacite.creatorFelissia, Fernando E.
datacite.creatorArea, Maria Cristina
datacite.creatorCabrera, Francisco
datacite.creatorCiudad, Gustavo A.
datacite.date2023
datacite.rightsAcceso abierto
datacite.subjectAdipic Acid
datacite.subjectFeast And Famine
datacite.subjectHemicellulose Hydrolysate
datacite.subjectLevulinic Acid
datacite.subjectMixed Microbial Cultures (mmc)
datacite.subjectAdipic Acid
datacite.subjectCellobiose
datacite.subjectFurfural
datacite.subjectLevulinic Acid
datacite.subjectLignocellulose
datacite.subjectXylose
datacite.subjectAdipic Acid
datacite.subjectCellobiose
datacite.subjectFurfural
datacite.subjectLevulinic Acid
datacite.subjectLignocellulose
datacite.subjectPolyhydroxybutyric Acid
datacite.subjectXylose
datacite.subjectArticle
datacite.subjectBacterial Growth
datacite.subjectBiosynthesis
datacite.subjectCarbon Source
datacite.subjectChemical Oxygen Demand
datacite.subjectGas Chromatography
datacite.subjectHunger
datacite.subjectMixed Cell Culture
datacite.subjectMixed Microbial Culture
datacite.subjectNonhuman
datacite.subjectRetention Time
datacite.subjectWaste Water Treatment Plant
datacite.titleToward the use of mixed microbial cultures for the biological production of adipic and levulinic acid
dc.contributor.authorPINTO IBIETA, FERNANDA EMILIA
dc.date.accessioned2025-10-06T14:21:53Z
dc.date.available2025-10-06T14:21:53Z
dc.description.abstractBiological synthesis of high added-value compounds like adipic acid (AA), levulinic acid (LA), or polyhydroxybutyrate (PHB) using pure culture has been separately reported. However, pure culture requires sterile conditions and the use of specific carbon sources resulting in high operating costs. Different alternatives based on the use of mixed microbial cultures (MMC) have been explored to resolve this problem. MMC have been widely reported for the production of PHB, but scarcely reported for LA production and never for AA synthesis. This work presents a novel strategy for the co-production of AA LA, and PHB using MMC. The strategy consists in selecting an MMC producer of AA, LA and PHB from an inoculum obtained from a wastewater treatment plant, which is then subjected to the feast and famine culture strategy in a sequential batch reactor, coupled with a batch reactor step to enhance the accumulation of AA and LA. The results showed that the MMC could produce a 16 ± 2, 23 ± 1 and 5 ± %1 (g compound/g volatile solids) of AA, LA and PHB, respectively, using a non-fermented residual biomass rich in pentose, namely synthetic hemicellulose hydrolysate (SHH) as the carbon source. These results contribute to generating future research to better understand and optimise the biosynthesis of these compounds by MMC. © 2023 Elsevier B.V., All rights reserved.
dc.description.ia_keywordproduction, acid, culture, reported, strategy, biological, synthesis
dc.formatPDF
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6850
dc.language.isoen
dc.publisherFrontiers Media
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceFrontiers in Microbiology
dc.subject.ia_odsODS 6: Agua limpia y saneamiento
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Biológicas
dc.subject.ia_oecd3nCiencias del Medio Ambiente
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2023
oaire.citationTitleFrontiers in Microbiology
oaire.citationVolume14
oaire.fundingReferenceANID FONDECYT 3210626 (Postdoctorado)
oaire.fundingReferenceEmergia Fellowship EMERGIA20_00114 (Andalucía)
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
relation.isAuthorOfPublication222c7a9b-189a-4a82-8d38-89ca7765bd44
relation.isAuthorOfPublication.latestForDiscovery222c7a9b-189a-4a82-8d38-89ca7765bd44
uct.catalogadorjvu
uct.comunidadIngenieríaen_US
uct.departamentoDepartamento Procesos Industriales
uct.facultadFacultad de Ingeniería
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionSCOPUS
uct.indizacionWOS
uct.indizacionDOAJ
uct.indizacionPubMed
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