Coatings of Cyclodextrin/Citric-Acid Biopolymer as Drug Delivery Systems: A Review

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datacite.alternateIdentifier.citationPharmaceutics, 15 (1), 2023
datacite.alternateIdentifier.doi10.3390/pharmaceutics15010296
datacite.alternateIdentifier.issn1999-4923
datacite.creatorEscobar, Karen
datacite.creatorGarrido-Miranda, Karla A.
datacite.creatorPulido, Ruth
datacite.creatorNaveas, Nelson
datacite.creatorManso, Miguel Jose
datacite.creatorHernández-Montelongo, Jacobo
datacite.date2023
datacite.rightsAcceso abierto
datacite.subjectCyclodextrin Polymers
datacite.subjectCyclodextrins
datacite.subjectDrug Delivery
datacite.subjectImplant Coating
datacite.subjectCaffeic Acid
datacite.subjectCarvacrol
datacite.subjectChlorhexidine
datacite.subjectChlorhexidine Acetate
datacite.subjectChlorhexidine Gluconate
datacite.subjectCiprofloxacin
datacite.subjectCitric Acid
datacite.subjectCyclodextrin
datacite.subjectDoxycycline
datacite.subjectEthoxzolamide
datacite.subjectFlorfenicol
datacite.subjectGentamicin
datacite.subjectIbuprofen
datacite.subjectMethylene Blue
datacite.subjectPaclitaxel
datacite.subjectPinocembrine
datacite.subjectPrednisolone
datacite.subjectRifampicin
datacite.subjectRopivacaine
datacite.subjectSimvastatin
datacite.subjectTriclosan
datacite.subjectVancomycin
datacite.subject4 Tert Butyl Benzoic Acid
datacite.subjectAntiinfective Agent
datacite.subjectBiopolymer
datacite.subjectCaffeic Acid
datacite.subjectCarvacrol
datacite.subjectChlorhexidine
datacite.subjectChlorhexidine Acetate
datacite.subjectChlorhexidine Gluconate
datacite.subjectCiprofloxacin
datacite.subjectCitric Acid
datacite.subjectCyclodextrin
datacite.subjectDoxycycline
datacite.subjectEthoxzolamide
datacite.subjectFlorfenicol
datacite.subjectGentamicin
datacite.subjectIbuprofen
datacite.subjectMethylene Blue
datacite.subjectPaclitaxel
datacite.subjectPinocembrine
datacite.subjectPrednisolone
datacite.subjectRifampicin
datacite.subjectRopivacaine
datacite.subjectSimvastatin
datacite.subjectTriclosan
datacite.subjectUnclassified Drug
datacite.subjectVancomycin
datacite.subjectArticle
datacite.subjectBiocompatibility
datacite.subjectChemical Structure
datacite.subjectCoating (procedure)
datacite.subjectControlled Study
datacite.subjectDrug Delivery System
datacite.subjectDrug Release
datacite.subjectDrug Synthesis
datacite.subjectGeometry
datacite.subjectHuman
datacite.subjectMathematical Model
datacite.subjectNonhuman
datacite.subjectPhysical Phenomena
datacite.subjectPolymerization
datacite.titleCoatings of Cyclodextrin/Citric-Acid Biopolymer as Drug Delivery Systems: A Review
dc.contributor.authorHERNANDEZ MONTELONGO, JESUS JACOBO
dc.description.abstractIn the early 2000s, a method for cross-linking cyclodextrins (CDs) with citric acid (CTR) was developed. This method was nontoxic, environmentally friendly, and inexpensive compared to the others previously proposed in the literature. Since then, the CD/CTR biopolymers have been widely used as a coating on implants and other materials for biomedical applications. The present review aims to cover the chemical properties of CDs, the synthesis routes of CD/CTR, and their applications as drug-delivery systems when coated on different substrates. Likewise, the molecules released and other pharmaceutical aspects involved are addressed. Moreover, the different methods of pretreatment applied on the substrates before the in situ polymerization of CD/CTR are also reviewed as a key element in the final functionality. This process is not trivial because it depends on the surface chemistry, geometry, and physical properties of the material to be coated. The biocompatibility of the polymer was also highlighted. Finally, the mechanisms of release generated in the CD/CTR coatings were analyzed, including the mathematical model of Korsmeyer Peppas, which has been dominantly used to explain the release kinetics of drug-delivery systems based on these biopolymers. The flexibility of CD/CTR to host a wide variety of drugs, of the in situ polymerization to integrate with diverse implantable materials, and the controllable release kinetics provide a set of advantages, thereby ensuring a wide range of future uses. © 2023 Elsevier B.V., All rights reserved.
dc.description.ia_keyworddrug, delivery, systems, release, method, citric, acid
dc.formatPDF
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5183
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourcePharmaceutics
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Físicas
dc.subject.ia_oecd3nQuímica
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2023
oaire.citationIssue1
oaire.citationTitlePharmaceutics
oaire.citationVolume15
oaire.fundingReferenceANID FONDECYT 11180395 (Regular)
oaire.fundingReferenceCONICYT PFCHA Doctorado Nacional 2017-21172001, 2015-21151648
oaire.fundingReferenceSpain Ministerio de Ciencia e Innovación PID2020-112770RB-C22
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
relation.isAuthorOfPublicationd1ebb975-fdac-4b8f-9131-a735b8c04d80
relation.isAuthorOfPublication.latestForDiscoveryd1ebb975-fdac-4b8f-9131-a735b8c04d80
uct.catalogadorjvu
uct.comunidadIngenieríaen_US
uct.departamentoDepartamento de Ciencias Matemáticas y Físicas
uct.facultadFacultad de Ingeniería
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed Central (PMC)
uct.indizacionEmbase
uct.indizacionChemical Abstracts Service (CAS)
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