Seminal plasma nerve growth factor signaling on the reproductive physiology of female llamas

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datacite.alternateIdentifier.citationAnimal Reproduction, 19 (4), 2022
datacite.alternateIdentifier.doi10.1590/1984-3143-AR2022-0116
datacite.alternateIdentifier.issn1806-9614
datacite.creatorPaiva, Luis
datacite.creatorSilva, Mauricio Erciario
datacite.creatorCarrasco, Rodrigo A.
datacite.creatorRatto, Vicente Francisco
datacite.creatorVargas, José Goicochea
datacite.creatorRatto, M. Hector
datacite.date2022
datacite.rightsAcceso abierto
datacite.subjectCamelids
datacite.subjectGnrh
datacite.subjectOvulation-inducing Factor
datacite.subjectSemen
datacite.titleSeminal plasma nerve growth factor signaling on the reproductive physiology of female llamas
dc.contributor.authorSILVA JIMENEZ, MAURICIO
dc.date.accessioned2025-10-06T14:21:39Z
dc.date.available2025-10-06T14:21:39Z
dc.description.abstractThe ovulation mechanism is one of the fascinating physiological processes in reproductive biology in mammals. From the reproductive point of view, the species have been classified as spontaneous or induced ovulators. Although the release of GnRH followed by the preovulatory LH surge is shared between both types of ovulation, the stimulus to initiate GnRH release varies between both categories. In spontaneous ovulators, ovulation depends on the systemic concentration of ovarian steroids, however, in induced ovulators, different stimuli such as copulation, environmental, and social cues can facilitate or induce ovulation regardless of the increases in systemic estradiol concentration. In this review, we document evidence that a male-derived protein is the main factor responsible for inducing ovulation and also modulating the ovarian function in the domestic South American camelid, the llama. The neurotrophin beta-Nerve Growth Factor (?-NGF) is the principal factor present in the semen of llamas responsible for inducing ovulation in this species. After the intrauterine deposit of semen during mating, ?-NGF is absorbed through the endometrium to reach the circulatory system, where it reaches the hypothalamus and stimulates GnRH release. The potential site of action of this neurotrophin at the brain has not been elucidated, however, hypotheses are raised that the factor may cross the blood-brain barrier and stimulate upstream neuronal networks that lead to the stimulation of GnRH-secreting neurons. It is possible that ?-NGF could be sensed at the median eminence without crossing the blood-brain barrier. Finally, it has been observed that this factor is not only a powerful stimulator of ovulation but also has a luteotrophic effect, resulting in the development of a corpus luteum capable of secreting more progesterone when compared to other ovulation-stimulating analogues. © 2023 Elsevier B.V., All rights reserved.
dc.description.ia_keywordovulation, factor, gnrh, reproductive, ovulators, release, brain
dc.formatPDF
dc.identifier.issn1984-3143
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6720
dc.language.isoen
dc.publisherColegio Brasileiro De Reproducao Animal
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceAnimal Reproduction
dc.subject.ia_odsODS 5: Igualdad de género
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Biológicas
dc.subject.ia_oecd3nBiología General
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2022
oaire.citationIssue4
oaire.citationTitleAnimal Reproduction
oaire.citationVolume19
oaire.fundingReferenceANID FONDECYT 3200439 (Postdoctorado), 1190980 (Regular)
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
relation.isAuthorOfPublication5a5fa19b-bce1-4387-8139-279b35112838
relation.isAuthorOfPublication.latestForDiscovery5a5fa19b-bce1-4387-8139-279b35112838
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Veterinarias y Salud Pública
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed
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