Cubebin, a Lignan Isolated from Drimys andina, Exhibits Potent and Selective Antiparasitic Activity against Angiostrongylus cantonensis

Simple item page
datacite.alternateIdentifier.citationACS Omega, 2025
datacite.alternateIdentifier.doi10.1021/acsomega.5c05451
datacite.alternateIdentifier.issn2470-1343
datacite.creatorTeixeira, Thainá R.
datacite.creatorSchmidt, Bernd
datacite.creatorSperlich, Eric
datacite.creatorLemes, Bruna L.
datacite.creatorAmaro, Monique C.
datacite.creatorPérez, Rebeca
datacite.creatorCéspedes-Méndez, Camilo
datacite.creatorVillegas, Cecilia
datacite.creatorBurgos, Viviana
datacite.creatorde Moraes, Josué
datacite.date2025
datacite.rightsAcceso abierto
datacite.subjectAssays
datacite.subjectDrug discovery
datacite.subjectInfectious diseases
datacite.subjectSafety
datacite.subjectToxicity
datacite.subject.englishEnsayos
datacite.subject.englishDescubrimiento de fármacos
datacite.subject.englishEnfermedades infecciosas
datacite.subject.englishSeguridad
datacite.subject.englishToxicidad
datacite.titleCubebin, a Lignan Isolated from Drimys andina, Exhibits Potent and Selective Antiparasitic Activity against Angiostrongylus cantonensis
dc.date.accessioned2025-10-06T14:21:36Z
dc.date.available2025-10-06T14:21:36Z
dc.description.abstractAngiostrongylus cantonensis is a zoonotic parasitic nematode of growing global health concern, largely due to the limited efficacy of current anthelmintics such as albendazole. In this study, cubebin —a dibenzylbutyrolactone lignan— was isolated for the first time from Drimys andina (Winteraceae), a Chilean endemic plant, and evaluated for its antiparasitic activity. Chromatographic purification of fresh leaves yielded cubebin as a 3:2 epimeric mixture, with its structure confirmed by 500 MHz NMR and single-crystal X-ray diffraction. In vitro assays demonstrated potent anthelmintic activity against both first-stage (L1) and infective third-stage (L3) larvae of A. cantonensis, with EC₅₀ values of 4.7 and 15.3 µM, respectively, making it approximately three times more potent than albendazole against L1 and comparably effective against L3. Cubebin exhibited no cytotoxicity toward monkey (Vero) or human (HaCaT) cell lines and no toxicity in Caenorhabditis elegans, indicating a favorable safety profile. In silico ADME analysis further revealed favorable pharmacokinetic and drug-likeness properties. These results highlight cubebin as a promising lead compound for the development of novel anthelmintic therapies targeting A. cantonensis and potentially other parasitic nematodes. © 2025 Elsevier B.V. All rights reserved.
dc.description.ia_keywordcubebin, cantonensis, against, activity, potent, angiostrongylus, parasitic
dc.formatPDF
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6698
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceACS Omega
dc.subject.ia_odsODS 3: Salud y bienestar
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Biológicas
dc.subject.ia_oecd3nBiología General
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2025
oaire.citationTitleACS Omega
oaire.fundingReferenceANID FONDECYT 1220831 (Regular)
oaire.fundingReferenceANID FONDEQUIP EQM220161
oaire.fundingReferenceFAPESP 2023/08418-6
oaire.fundingReferenceCNPq 312211/2021-0
oaire.fundingReferenceCAPES 001
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Biológicas y Químicas
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed Central (PMC)
uct.indizacionDOAJ
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Teixeira et al. - ACS Omega - Cubebin, a Lignan Isolated fro.pdf
Size:
3.89 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Producción Alimentaria