Synthesis and characterization of a novel colorimetric and fluorometric probe Turn-on for the detection of Cu2+ of derivatives rhodamine
Date
Authors
GARCIA SANHUEZA, CAMILO ANDRES
Segura, Camilo
Yañez, Osvaldo
Galdámez, Antonio
Tapia, Victoria
Núñez, Marco Tulio
Osorio-Román, Igor Orlando
García, Camilo
García-Beltrán, Olimpo
Segura, Camilo
Yañez, Osvaldo
Galdámez, Antonio
Tapia, Victoria
Núñez, Marco Tulio
Osorio-Román, Igor Orlando
García, Camilo
García-Beltrán, Olimpo
Authors
Date
Datos de publicación:
10.1016/j.jphotochem.2022.114278
Keywords
Chemosensor - Colorimetric Fluorescent Dye - Cu2+ Ions - Rhodamine Derivate - Turn-on
Collections
Abstract
A new Rhodamine-based Turn On fluorescent probe (E)- 3?,6?-bis(diethylamino)-2-((2,5-dimethoxybenzylidene)amino)spiro[isoindoline-1,9?-xanthen]-3-one (WGB) was synthesized. Results show that WGB is selective for Cu2+ cations, forming a WGB-Cu2+ complex in a 2:1 stoichiometry, confirmed through density functional theory (DFT) electronic structure calculations and reactive molecular dynamics (MD) simulations. Theoretical calculations agreed with the experimental data. The detection limit of WGB-Cu+2 complex is 6.76 × 10-8 M. Preliminary studies employing epifluorescence microscopy demonstrate that Cu2+ can be imaged in neuroblastoma SH-SY5Y cells treated with WGB. © 2022 Elsevier B.V., All rights reserved.
Description
Keywords
Chemosensor , Colorimetric Fluorescent Dye , Cu2+ Ions , Rhodamine Derivate , Turn-on
Citation
10.1016/j.jphotochem.2022.114278