Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment

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datacite.alternateIdentifier.citationInternational Journal of molecular sciences, Vol. 25,2024
datacite.alternateIdentifier.doi10.3390/ijms25105189
datacite.creatorCortez, Nicole
datacite.creatorVillegas, Cecilia
datacite.creatorBurgos, Viviana
datacite.creatorOrtiz, Leandro
datacite.creatorCabrera Pardo, Jaime R.
datacite.creatorPaz, Cristian
datacite.date2024
datacite.rightsAcceso abierto
datacite.subjectÁcido clorogénico
datacite.subjectCGA
datacite.subjectQuimiorresistencia
datacite.subjectToxicidad inducida por quimioterapia
datacite.subject.englishchlorogenic acid
datacite.subject.englishCGA
datacite.subject.englishchemoresistance
datacite.subject.englishchemotherapy-induced toxicity
datacite.titleTherapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
dc.date.accessioned10-09-2024 15:47
dc.date.available10-09-2024 15:47
dc.description.abstractChemotherapeutic drugs are indispensable in cancer treatment, but their effectiveness is often lessened because of non-selective toxicity to healthy tissues, which triggers inflammatory pathways that are harmful to vital organs. In addition, tumors' resistance to drugs causes failures in treatment. Chlorogenic acid (5-caffeoylquinic acid, CGA), found in plants and vegetables, is promising in anticancer mechanisms. In vitro and animal studies have indicated that CGA can overcome resistance to conventional chemotherapeutics and alleviate chemotherapy-induced toxicity by scavenging free radicals effectively. This review is a summary of current information about CGA, including its natural sources, biosynthesis, metabolism, toxicology, role in combatting chemoresistance, and protective effects against chemotherapy-induced toxicity. It also emphasizes the potential of CGA as a pharmacological adjuvant in cancer treatment with drugs such as 5-fluorouracil, cisplatin, oxaliplatin, doxorubicin, regorafenib, and radiotherapy. By analyzing more than 140 papers from PubMed, Google Scholar, and SciFinder, we hope to find the therapeutic potential of CGA in improving cancer therapy.
dc.description.ia_keywordcancer, treatment, drugs, toxicity, acid, potential, resistance
dc.formatPDF
dc.identifier.issn1422-0067
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6012
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourceInternational Journal of Molecular Sciences
dc.subject.ia_oecd1nCiencias Médicas y de la Salud
dc.subject.ia_oecd2nMedicina Clínica
dc.subject.ia_oecd3nMedicina Clínica
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2024
oaire.citationIssue10
oaire.citationTitleInternational Journal of Molecular Sciences
oaire.citationVolume25
oaire.fundingReferenceANID FONDECYT 1220831
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo de Revisión
oaire.resourceType.enReview
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Biológicas y Químicas
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed Central (PMC)
uct.indizacionChemical Abstracts Service (CAS)
uct.indizacionMEDLINE
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