Characterization of alginate from Antarctic Himantothallus grandifolius (Phaeophyceae) and preparation of polyelectrolyte complexes with chitosan

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datacite.alternateIdentifier.doi10.1002/app.54688
datacite.alternateIdentifier.issn0021-8995
datacite.creatorCandia, Carolina
datacite.creatorGallardo-Moya, Daniel
datacite.creatorGuerrero, Juan
datacite.creatorLeal, David
datacite.creatorMansilla, Andres
datacite.creatorMartinez-Gomez, Fabian
datacite.creatorMatsuhiro, Betty
datacite.creatorYanez-S, Mauricio
datacite.date2023
datacite.rightsAcceso restringido
datacite.subjectAlginato
datacite.subjectQuitosano
datacite.subjectLiberación de Fármacos
datacite.subjectHimantothallus Grandifolius
datacite.subjectHidrogeles
datacite.subjectComplejos Polielectrolíticos
datacite.subject.englishAlginate
datacite.subject.englishChitosan
datacite.subject.englishDrug release
datacite.subject.englishHimantothallus grandifolius
datacite.subject.englishHydrogels
datacite.subject.englishPolyelectrolyte complexes
datacite.titleCharacterization of alginate from Antarctic Himantothallus grandifolius (Phaeophyceae) and preparation of polyelectrolyte complexes with chitosan
dc.date.accessioned5/27/24 14:26
dc.date.available5/27/24 14:26
dc.description.abstractHydrogels are three-dimensional polymeric materials with applications in various areas such as biomedicine, tissue engineering, pollutant capture systems, and so forth. However, its application is limited due to the reproducibility of its properties. Factors such as the composition of the constituents, the type of union between the polymer chains, and the crosslinking time play a crucial role in ensuring its reproducibility. In this study, the objective is to prepare a matrix with well-defined properties that ensure controlled release processes. Treatment of Himantothallus grandifolius with Na2CO3 aqueous solution afforded in 18.9% yield alkaline extract. Hydrogels were prepared by ionic complexation of alginate from H. grandifolius, and polyguluronate enriched alginate from Desmarestia ligulata with chitosan stabilized by immersion in 0.1 M CaCl2 solution; better swelling ratio in water was found for hydrogels with low molecular weight chitosan (MW 125,000 g/mol) than those with medium molecular weight chitosan (MW450,000-500,000 g/mol). Liberation of the model drug metformin hydrochloride from alginates: chitosan complexes (3:1) at pH 1.5 was especially low for hydrogel from H. grandifolius during the first 2 h; 70% of metformin was released at pH 6.5 after 24 h. This polyelectrolyte complex constitutes a good material for potential application in biomedicine considering its cationic and anionic characteristics.
dc.description.ia_keywordchitosan, grandifolius, hydrogels, alginate, such, biomedicine, application
dc.formatPDF
dc.identifier.issn0021-8995
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5638
dc.language.isoen
dc.publisherWiley
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceJournal of Applied Polymer Science
dc.subject.ia_odsODS 6: Agua limpia y saneamiento
dc.subject.ia_oecd1nIngeniería y Tecnología
dc.subject.ia_oecd2nMateriales
dc.subject.ia_oecd3nCiencia de los Materiales
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2023
oaire.citationIssue46
oaire.citationTitleJournal of Applied Polymer Science
oaire.citationVolume140
oaire.fundingReferenceUSACH 021641MY (DICYT)
oaire.fundingReferenceANID FONDECYT 1110875, 1180433 (Regular), EQM150106 (FONDEQUIP)
oaire.licenseConditionWiley Periodicals LLC. © 2023
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Biológicas y Químicas
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionSCOPUS
uct.indizacionDOAJ
uct.indizacionWOS
uct.indizacionPubMed
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