Anticandidal activity of Clinopodium chilense essential oil

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datacite.alternateIdentifier.citationFrontiers in Pharmacology, 16, 2025
datacite.alternateIdentifier.doi10.3389/fphar.2025.1634250
datacite.alternateIdentifier.issn1663-9812
datacite.creatorMontenegro, Iván J.
datacite.creatorVillarroel, Constanza
datacite.creatorMuñoz-Núñez, Evelyn
datacite.creatorMena-Ulecia, Karel
datacite.creatorSilva, Valentina
datacite.creatorMadrid, Alejandro M.
datacite.date2025
datacite.rightsAcceso abierto
datacite.subjectCandida Spp
datacite.subjectClinopodium Chilense
datacite.subjectEssential Oil
datacite.subjectPulegone
datacite.subjectThymol
datacite.subjectIsomenthone
datacite.subjectProtein
datacite.subjectPulegone
datacite.subjectSterol 14alpha Demethylase
datacite.subjectThymol
datacite.subjectCorei7
datacite.subjectHewlett Packard 5973
datacite.subjectHewlett Packard 6890
datacite.subjectIntel
datacite.subjectSigma Plot
datacite.subjectStatistica 7.0
datacite.subjectVersa Max
datacite.subjectXcalibur
datacite.subjectAls9-2 Protein
datacite.subjectEssential Oil
datacite.subjectIsomenthone
datacite.subjectProtein
datacite.subjectPulegone
datacite.subjectSterol 14alpha Demethylase
datacite.subjectThymol
datacite.subjectUnclassified Drug
datacite.subjectAntifungal Activity
datacite.subjectArticle
datacite.subjectCandida
datacite.subjectCandida Glabrata
datacite.subjectCandida Tropicalis
datacite.subjectCell Viability Assay
datacite.subjectChemical Composition
datacite.subjectClavispora Lusitaniae
datacite.subjectClinical Assessment
datacite.subjectClinopodium Chilense
datacite.subjectControlled Study
datacite.subjectCytotoxicity
datacite.subjectHek293t Cell Line
datacite.subjectHuman
datacite.subjectHuman Cell
datacite.subjectMass Fragmentography
datacite.subjectMeyerozyma Guilliermondii
datacite.subjectMinimum Fungicidal Concentration
datacite.subjectMinimum Inhibitory Concentration
datacite.subjectMolecular Docking
datacite.subjectMolecular Dynamics
datacite.subjectNonhuman
datacite.subjectPharmacokinetic Parameters
datacite.subjectPhysicochemical Model
datacite.subjectPlant
datacite.subjectSpectrophotometry
datacite.subjectToxicological Parameters
datacite.titleAnticandidal activity of Clinopodium chilense essential oil
dc.contributor.authorMENA ULECIA, KAREL
dc.date.accessioned2025-10-06T14:21:53Z
dc.date.available2025-10-06T14:21:53Z
dc.description.abstractThe antifungal activity of the essential oil of Clinopodium chilense (Benth.) Govaerts was investigated against several strains of Candida spp. including clinical isolates and reference strains. Antifungal efficacy was evaluated by determining minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). The chemical composition of the essential oil, characterized by gas chromatography-mass spectrometry (GC/MS), revealed pulegone (18.5%), thymol (11.0%), and isomenthone (10.0%) as the primary constituents. Clinopodium chilense essential oil (EO) demonstrated broad-spectrum anticandidal activity against all tested Candida spp., with MIC values ranging from 16 to 64 ?g/mL and MFC values from 16 to 128 ?g/mL. The EO exhibited potent fungicidal activity (MFC/MIC ratio ?2) against several strains, notably Candida tropicalis (MIC and MFC of 16 ?g/mL), and also showed efficacy against C. guilliermondii and C. lusitaniae. Among the major components, thymol generally displayed the lowest MIC values (32 64 ?g/mL). Molecular docking studies further suggested thymol as a key contributor to the oil s antifungal effect, showing strong binding affinities to C. albicans virulence proteins Als9-2 and the enzyme CYP51. Significantly, the essential oil outperformed amphotericin B against all tested clinical isolates. Overall, C. chilense EO exhibits significant fungistatic and fungicidal activity against pathogenic Candida species without affecting normal cell viability. These findings, supported by chemical characterization and in silico analysis of its major components like thymol, highlight its potential as a source of novel natural antifungal agents. © 2025 Elsevier B.V., All rights reserved.
dc.description.ia_keywordagainst, activity, essential, antifungal, chilense, candida, thymol
dc.formatPDF
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6851
dc.language.isoen
dc.publisherFrontiers Media
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourceFrontiers in Pharmacology
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Biológicas
dc.subject.ia_oecd3nBiología General
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2025
oaire.citationTitleFrontiers in Pharmacology
oaire.citationVolume16
oaire.fundingReferenceANID FONDECYT 1230311 (Regular)
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
relation.isAuthorOfPublication7073b065-ad61-4799-9cbf-45500a019334
relation.isAuthorOfPublication.latestForDiscovery7073b065-ad61-4799-9cbf-45500a019334
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Biológicas y Químicas
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionSCOPUS
uct.indizacionWOS
uct.indizacionDOAJ
uct.indizacionPubMed
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