Pharmacokinetics of propofol in 10 to 15 days old foals
Pharmacokinetics of propofol in 10 to 15 days old foals
Authors
Baroni, E
Ahumada, F
Luders, C
Saavedra, I
Zambucetti, R
Ahumada, F
Luders, C
Saavedra, I
Zambucetti, R
Authors
Date
Datos de publicaciĆ³n:
ARCHIVOS DE MEDICINA VETERINARIA,Vol.32,193-200,2000
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Abstract
Pharmacokinetic variables of propofol were studied in 8 foals. Plasma levels of propofol at different time after a single intravenous dose of 2.4 mg/kg bw, were determined by HPLC. An open two compartments model was used to evaluate plasma levels of propofol and values of t(1/2)alpha, t(1/2)beta Vd(c), Vd(ss), Vd beta, Cl-total y MRT were obtained. Propofol pharmacokinetic disposition showed a rapid distribution and removal from organic tissues, and the reported pharmacokinetic variables contribute to determine the appropriate dose to be given.