Carbonate-beta-Cyclodextrin-Based Nanosponge as a Nanoencapsulation System for Piperine: Physicochemical Characterization
- Garrido, B. - Gonzalez, S. - Hermosilla, J. - Millao, S. - Quilaqueo, M. - Guineo, J. - Acevedo, F. - Pesenti Pérez, Héctor - Rolleri, A. - Shene, C. - Rubilar, M.
- Datos de publicación:
- JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION,Vol.19,620-630,2019
- Piperine - beta-Cyclodextrin - Nanosponges - Nanoencapsulation - Solvent method - Inclusion complex
- Migración Web of Science 
- Piperine (PIP) is a nitrogenous substance whose application in food is still limited due to its low solubility in water, low bioavailability, and high pungency. Nanosponges (NS) can selectively capture, transport, and release a wide variety of substances and mask unpleasant flavors. The objective of this study was to evaluate carbonate-beta-cyclodextrin-based NS formation as a nanoencapsulation system for PIP. The NS were formed with a cyclic oligosaccharide (beta-cyclodextrin) to a cross-linker (diphenyl carbonate) at molar ratios of 1:2, 1:6, and 1:10 by the solvent method at 90, 120, and 150 degrees C for 5 h. Only molar ratios of 1:6 and 1:10 formed NS. The NS 1:6 at 90 degrees C with loading efficiency of 42.6% +/- 1.1 was the best alternative for loading PIP in the NS matrix because it had the lowest absorbance of cyclic carbonates and required the lowest amount of cross-linker in its formation. The ability of the cyclodextrin-based NS to encapsulate PIP was confirmed by FTIR studies and hyperspectral FTIR images, TGA, and DSC, showing that PIP is dispersed, not forming large clusters, or concentrating in a single zone. NS are an effective PIP encapsulation system and protect the bioactive properties of the PIP.