Association of polymorphisms within the Renin-Angiotensin System with metabolic syndrome in a cohort of Chilean subjects
- Herrera, Christian L. - Castillo, Wilma - Estrada, Patricia - Mancilla, Barbara - Reyes, Gerardo - Saavedra, Nicolas - Guzman Oyarzo, Neftali - Seron, Pamela - Lanas, Fernando - Salazar, Luis A.
- Datos de publicación:
- ARCHIVES OF ENDOCRINOLOGY METABOLISM,Vol.60,190-198,2016
- Metabolic syndrome - gender - polymorphisms - renin-angiotensin system
- Migración Web of Science 
- Objective: Metabolic syndrome (MetS) is associated with hypertension, obesity and dyslipidemia. Thus, genetic variants related with these conditions may modulate its development. We evaluated the effect of polymorphisms in the renin-angiotensin system (RAS) on metabolic syndrome risk in a cohort of Chilean subjects. Subjects and methods: A total of 152 subjects, 83 with MetS (51.2 +/- 9.6 years) and 69 without MetS (49.5 +/- 9.3 years) of both genders were included, according to the ATP III update criteria. The rs4340 Insertion/Deletion (I/D), rs699 (T>C) and rs5186 (A>C) of the ACE, AGT and AGTR1 genes, respectively, were genotyped. Results: After adjusting for age and gender, we observed the DD genotype of rs4340 associated with MetS (p = 0.02). Specifically, the DD genotype was associated with MetS risk in women (OR = 4.62, 95% CI, 1.41 - 15.04; p < 0.01). In males, the AA genotype for rs5186 variant was associated with an increased risk for developing MetS when compared with women carrying the same genotype (OR = 3.2; 95% CI, 1.03 - 9.89; p = 0.04). In subjects without MetS, DD genotype was associated with increased waist circumference (p = 0.023) while subjects with MetS carrying the rs5186 TT genotype showed higher levels of HDL-cholesterol (p = 0.031). Conclusion: The present study contributes data highlighting the role for RAS polymorphisms in predisposing to metabolic syndrome in Chilean subjects.