Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance

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dc.contributor.authorReyes, Maria Elena
dc.contributor.authorRiquelme, Ismael
dc.contributor.authorSalvo, Tomas
dc.contributor.authorZanella, Louise
dc.contributor.authorLetelier, Pablo
dc.contributor.authorBrebi, Priscilla
dc.date2020
dc.date.accessioned2021-04-30T16:46:59Z
dc.date.available2021-04-30T16:46:59Z
dc.description.abstractFucoidans are sulphated polysaccharides that can be obtained from brown seaweed and marine invertebrates. They have anti-cancer properties, through their targeting of several signaling pathways and molecular mechanisms within malignant cells. This review describes the chemical structure diversity of fucoidans and their similarity with other molecules such as glycosaminoglycan, which enable them to participation in diverse biological processes. Furthermore, this review summarizes their influence on the development of metastasis and drug resistance, which are the main obstacles to cure cancer. Finally, this article discusses how fucoidans have been used in clinical trials to evaluate their potential synergy with other anti-cancer therapies.
dc.identifier.citationMARINE DRUGS,Vol.18,,2020
dc.identifier.doi10.3390/md18050232
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3456
dc.language.isoen
dc.publisherMDPI
dc.sourceMARINE DRUGS
dc.subject.englishfucoidan
dc.subject.englishcancer
dc.subject.englishmetastasis
dc.subject.englishepithelial mesenchymal transition
dc.subject.englishnanoparticles
dc.titleBrown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance
dc.typeReview
uct.catalogadorWOS
uct.indizacionSCI
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