Distribution of GnRH and Kisspeptin Immunoreactivity in the Female Llama Hypothalamus

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dc.contributor.authorBerland Olea, Marco
dc.contributor.authorPaiva, Luis
dc.contributor.authorAlondra Santander, Lig
dc.contributor.authorHector Ratto, Marcelo
dc.date2021
dc.date.accessioned2021-04-30T16:35:23Z
dc.date.available2021-04-30T16:35:23Z
dc.description.abstractLlamas are induced non-reflex ovulators, which ovulate in response to the hormonal stimulus of the male protein beta-nerve growth factor (beta-NGF) that is present in the seminal plasma; this response is dependent on the preovulatory gonadotrophin-releasing hormone (GnRH) release from the hypothalamus. GnRH neurones are vital for reproduction, as these provide the input that controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. However, in spontaneous ovulators, the activity of GnRH cells is regulated by kisspeptin neurones that relay the oestrogen signal arising from the periphery. Here, we investigated the organisation of GnRH and kisspeptin systems in the hypothalamus of receptive adult female llamas. We found that GnRH cells exhibiting different shapes were distributed throughout the ventral forebrain and some of these were located in proximity to blood vessels; sections of the mediobasal hypothalamus (MBH) displayed the highest number of cells. GnRH fibres were observed in both the organum vasculosum laminae terminalis (OVLT) and median eminence (ME). We also detected abundant kisspeptin fibres in the MBH and ME; kisspeptin cells were found in the arcuate nucleus (ARC), but not in rostral areas of the hypothalamus. Quantitative analysis of GnRH and kisspeptin fibres in the ME revealed a higher innervation density of kisspeptin than of GnRH fibres. The physiological significance of the anatomical findings reported here for the ovulatory mechanism in llamas is still to be determined.
dc.identifier.citationFRONTIERS IN VETERINARY SCIENCE,Vol.7,,2021
dc.identifier.doi10.3389/fvets.2020.597921
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3179
dc.language.isoen
dc.publisherFRONTIERS MEDIA SA
dc.sourceFRONTIERS IN VETERINARY SCIENCE
dc.subject.englishLHRH
dc.subject.englishmetastin
dc.subject.englishOVLT
dc.subject.englishmedian eminence
dc.subject.englishinduced ovulation
dc.subject.englishllama glama
dc.subject.englishcamelids
dc.titleDistribution of GnRH and Kisspeptin Immunoreactivity in the Female Llama Hypothalamus
dc.typeArticle
uct.catalogadorWOS
uct.indizacionSCI
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