Muscle Quality Index in Morbidly Obesity Patients Related to Metabolic Syndrome Markers and Cardiorespiratory Fitness
Muscle Quality Index in Morbidly Obesity Patients Related to Metabolic Syndrome Markers and Cardiorespiratory Fitness
Authors
Caamano Navarrete, Felipe
Jerez Mayorga, Daniel
Alvarez, Cristian
del Cuerpo, Indya
Cresp Barria, Mauricio
Delgado Floody, Pedro
Jerez Mayorga, Daniel
Alvarez, Cristian
del Cuerpo, Indya
Cresp Barria, Mauricio
Delgado Floody, Pedro
Authors
Date
Datos de publicaciĆ³n:
NUTRIENTS,Vol.15,,2023
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Abstract
Background: Muscle quality index (MQI) is an emerging health indicator obtained by dividing handgrip strength by body mass index (BMI) that needs to be studied in morbidly obese patients (defined by BMI >= 35 kg/m(2)). Objective: To determine the association between MQI, metabolic syndrome (MetS) markers, and cardiorespiratory fitness (CRF), and as a second objective to determine the potential mediation role of MQI in the relationship between abdominal obesity and systolic blood pressure (SBP) in this sample. Methods: This cross-sectional study included 86 severely/morbidly obese patients (age = 41.1 +/- 11.9 y, nine men). MQI, metabolic syndrome markers, CRF, and anthropometric parameters were measured. Two groups were developed according to MQI; High-MQI (n = 41) and Low-MQI (n = 45). Results: The Low-MQI group reported higher abdominal obesity (High-MQI: 0.7 +/- 0.1 vs. Low-MQI: 0.8 +/- 0.1 WC/height; p = 0.011), SBP (High-MQI: 133.0 +/- 17.5 vs. Low-MQI: 140.1 +/- 15.1 mmHg; p = 0.048), and lower CRF (High-MQI; 26.3 +/- 5.9 vs. Low-MQI; 22.4 +/- 6.1 mL/kg/min, p = 0.003) than the High-MQI group. Waist-to-height ratio (beta: -0.07, p = 0.011), SBP (beta: -18.47, p = 0.001), and CRF (beta: 5.21, p = 0.011) were linked to MQI. In a mediation model, the indirect effect confirms that MQI is a partial mediator of the association between abdominal obesity with SBP. Conclusions: MQI in morbidly obesity patients reported an inverse association with MetS markers and a positive association with CRF (VO2(max)). It mediates the relationship between abdominal obesity and SBP.