Frequency and Specificity of Red Blood Cell Alloimmunization in Chilean Transfused Patients

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dc.contributor.authorCaamano, Jose
dc.contributor.authorMusante, Evangelina
dc.contributor.authorContreras, Margarita
dc.contributor.authorUlloa, Hernan
dc.contributor.authorReyes, Carolina
dc.contributor.authorInaipil, Veronica
dc.contributor.authorSaavedra, Nicolas
dc.contributor.authorGuzman Oyarzo, Neftali
dc.date2015
dc.date.accessioned2021-04-30T17:05:03Z
dc.date.available2021-04-30T17:05:03Z
dc.description.abstractBackground: Alloimmunization is an adverse effect of blood transfusions. In Chile, alloimmunization frequency is not established, and for this reason the aim of this study was to investigate the prevalence and specificity of red blood cell (RBC) alloantibodies in Chilean transfused subjects. Methods: Records from 4,716 multi-transfused patients were analyzed. In these patients, antibody screening was carried out prior to cross-matching with a commercially available two-cell panel by the microcolum gel test, and samples with a positive screen were analyzed for the specificity of the alloantibody with a 16-cell identification panel. Results: The incidence of RBC alloimmunization in transfused patients was 1.02% (48/4,716) with a higher prevalence in women (40/48). We detected 52 antibodies, the most frequent specificities identified were anti-E (30.8%), anti-K (26.9%), anti-D (7.7%), and anti-Fy(a) (5.8%). The highest incidence of alloantibodies was observed in cancer and gastroenterology patients. Conclusion: The data demonstrated a low alloimmunization frequency in Chilean transfused patients, principally associated with antibodies anti-E, anti-K, anti-D, and anti-Fy(a).
dc.identifier.citationTRANSFUSION MEDICINE AND HEMOTHERAPY,Vol.42,4-7,2015
dc.identifier.doi10.1159/000370136
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3901
dc.language.isoen
dc.publisherKARGER
dc.sourceTRANSFUSION MEDICINE AND HEMOTHERAPY
dc.subject.englishAlloimmunization
dc.subject.englishUnexpected antibodies
dc.subject.englishRed blood cell transfusion
dc.titleFrequency and Specificity of Red Blood Cell Alloimmunization in Chilean Transfused Patients
dc.typeArticle
uct.catalogadorWOS
uct.indizacionSCI
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