Chronic hypobaric hypoxia diminishes the expression of base excision repair OGG1 enzymes in spermatozoa

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dc.contributor.authorFarías, Jorge G.
dc.contributor.authorZepeda, A.
dc.contributor.authorCastillo, R.
dc.contributor.authorFigueroa Villalobos, Elías
dc.contributor.authorAdemoyero, O.T.
dc.contributor.authorPulgar, V.M
dc.date2018
dc.date.accessioned2020-04-06T22:29:05Z
dc.date.available2020-04-06T22:29:05Z
dc.description.abstractHypobaric hypoxia induces DNA damage in rat testicular cells, the production of defective spermatozoids and decreased sperm count, associated with an increase in oxidative stress. 8-Oxoguanine glycosylase (OGG1) enzymes are main members of the base excision repair (BER) system, a DNA repair mechanism. We determined the expression levels of mitochondrial and nuclear OGG1 isoforms in spermatozoa collected from cauda epididymis in rats exposed to chronic hypobaric hypoxia (CHH) for 5, 15 and 30 days. CHH attenuates OGG1 expression in a time-dependent fashion, with a greater reduction in the mitochondrial isoform OGG1-2a (p <.05). Attenuation of the BER system may contribute to DNA damage under hypoxia exposureen_US
dc.formatPDFen_US
dc.identifier.citationAndrología, Vol.50, N°2, e12876, 2018en_US
dc.identifier.doi10.1111/and.12876en_US
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/2151
dc.language.isoenen_US
dc.sourceAndrologíaen_US
dc.subjectInfertilidaden_US
dc.subjectEstrés oxidativoen_US
dc.subjectDaño en el ADNen_US
dc.titleChronic hypobaric hypoxia diminishes the expression of base excision repair OGG1 enzymes in spermatozoaen_US
dc.typeArtículo de Revistaen_US
uct.catalogadorpopen_US
uct.comunidadCiencias de la Saluden_US
uct.indizacionISI - Science Citation Indexen_US
uct.indizacionSCOPUSen_US
uct.nucleosNúcleo en Producción Alimentariaen_US
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