The Wing-Spot and the Comet Tests as Useful Assays Detecting Genotoxicity in Drosophila

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dc.contributor.authorMarcos, Ricard
dc.contributor.authorCarmona Ortíz, Erico
dc.contributor.authorDhawan, A
dc.contributor.authorBajpayee, M
dc.date2013
dc.date.accessioned2021-04-30T16:35:24Z
dc.date.available2021-04-30T16:35:24Z
dc.description.abstractIn spite of its pioneer use in detecting mutational processes, Drosophila has yet an important role in studies aiming to detect and quantify the induction of DNA damage. Here we describe two assays, one detecting primary damage (the Comet assay) and the other detecting somatic mutation and recombination effects (wing-spot test). It is important to emphasize that somatic recombination is a key event in cancer and no assays exist to detect and quantify somatic recombination processes, other than the spot tests developed in Drosophila.
dc.identifier.citationGENOTOXICITY ASSESSMENT: METHODS AND PROTOCOLS,Vol.1044,417-427,2013
dc.identifier.doi10.1007/978-1-62703-529-3_23
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3189
dc.language.isoen
dc.publisherHUMANA PRESS INC
dc.sourceGENOTOXICITY ASSESSMENT: METHODS AND PROTOCOLS
dc.subject.englishDrosophila
dc.subject.englishGenotoxicity
dc.subject.englishComet assay
dc.subject.englishWing-spot test
dc.subject.englishDNA damage
dc.titleThe Wing-Spot and the Comet Tests as Useful Assays Detecting Genotoxicity in Drosophila
uct.catalogadorWOS
uct.indizacionBSCI
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