Fractal analysis of the formation process and morphologies of hyaluronan/chitosan nanofilms in layer-by-layer assembly

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dc.contributor.authorHernandez Montelongo, J.
dc.contributor.authorNascimento, V. F.
dc.contributor.authorHernandez Montelongo, R.
dc.contributor.authorBeppu, M. M.
dc.contributor.authorCotta, M. A.
dc.date2020
dc.date.accessioned2021-04-30T16:47:48Z
dc.date.available2021-04-30T16:47:48Z
dc.description.abstractIn the last decade, hyaluronan (HA, polyanion) and chitosan (CHI, polycation) biopolymers have been assembled by layer-by-layer (LbL) for the synthesis of antibacterial coatings. As electrostatic interactions are the main driving force for the formation of LbL films, pH and ionic strength (IS) are important critical variables of synthesis. In this context, we used surface fractal analysis of HA/CHI films to characterize the growth process for different bilayers obtained with two pH (5 and 3) and IS values (0 and 0.1 M NaCl). Our results showed that the HA/CHI assembling is mainly affected by changes in the pH than IS. Fractal dimension (D-f) of pH 5 series presented values similar to 2.2, indicating that irregularities from the initial random adsorption process are minimized. However, when pH decreased to 3, D-f increases up to similar to 2.5, suggesting a transition to diffusion-limited aggregation.
dc.identifier.citationPOLYMER,Vol.191,,2020
dc.identifier.doi10.1016/j.polymer.2020.122283
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3545
dc.language.isoen
dc.publisherELSEVIER SCI LTD
dc.sourcePOLYMER
dc.subject.englishFractal analysis
dc.subject.englishHyaluronan/chitosan nanofilms
dc.subject.englishLayer-by-layer
dc.titleFractal analysis of the formation process and morphologies of hyaluronan/chitosan nanofilms in layer-by-layer assembly
dc.typeArticle
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