Molecular aspects of breast cancer resistance to drugs (Review)

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dc.contributor.authorCalaf, Gloria M.
dc.contributor.authorZepeda, Andrea B.
dc.contributor.authorCastillo, Rodrigo L.
dc.contributor.authorFigueroa, Carolina A.
dc.contributor.authorArias, Consuelo
dc.contributor.authorFigueroa Villalobos, Elías
dc.contributor.authorFarias, Jorge G.
dc.date2015
dc.date.accessioned2021-04-30T17:05:04Z
dc.date.available2021-04-30T17:05:04Z
dc.description.abstractDespite continuous advances in the knowledge of breast cancer pathophysiology, this type of neoplasia remains a leading cause of cancer-related death in women worldwide. Carcinogenesis takes a progressive course from somatic mutations, alteration of the DNA repair mechanisms, inhibition of growth suppressors, followed by cell proliferation, tissue invasion and risk of metastasis. Less than 10% of all cancers are hereditary, and in the case of breast cancer only 8%, a phenomenon linked to genetic changes in BRCA1 or BRCA2. All the other cancers can be caused by an infection (15%) or in most cases (75%) the etiology is unknown. Patients with genetic mutations in BRCA1 or BRCA2 have 30-60% likelihood of developing a second primary breast cancer and between 11 and 45% risk of ovarian cancer, HER-2/neu is overexpressed in similar to 30% of human breast tumors and it has a predictive role in chemotherapy and endocrine therapy.
dc.identifier.citationINTERNATIONAL JOURNAL OF ONCOLOGY,Vol.47,437-445,2015
dc.identifier.doi10.3892/ijo.2015.3055
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3924
dc.language.isoen
dc.publisherSPANDIDOS PUBL LTD
dc.sourceINTERNATIONAL JOURNAL OF ONCOLOGY
dc.subject.englishbreast cancer
dc.subject.englishmultidrug resistance
dc.subject.englishcancer classifications
dc.titleMolecular aspects of breast cancer resistance to drugs (Review)
dc.typeArticle
uct.catalogadorWOS
uct.indizacionSCI
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