Genotoxicity of copper oxide nanoparticles in Drosophila melanogaster

Simple item page
dc.contributor.authorCarmona Ortíz, Erico
dc.contributor.authorInostroza Blancheteau, Claudio
dc.contributor.authorObando, Veroska
dc.contributor.authorRubio, Laura
dc.contributor.authorMarcos, Ricard
dc.date2015
dc.date.accessioned2021-04-30T16:59:15Z
dc.date.available2021-04-30T16:59:15Z
dc.description.abstractCopper oxide nanoparticles (CuONPs) are used as semiconductors, catalysts, gas sensors, and antimicrobial agents. We have used the comet and wing-spot assays in Drosophila melanogaster to assess the genotoxicity of CuONPs and ionic copper (CuSO4). Lipid peroxidation analysis was also performed (Thiobarbituric Acid Assay, TBARS). In larval hemocytes, both CuONPs and CuSO4 caused significant dose-dependent increases in DNA damage (comet assay). In the wing-spot assay, an increase in the frequency of mutant spots was observed in the wings of the adults; CuONPs were more effective than was CuSO4. Both agents induced TBARS; again, CuONPs were more active than was CuSO4. The results indicate that CuONPs are genotoxic in Drosophila, and these effects may be mediated by oxidative stress. Most of the effects appear to be related to the presence of copper ions. (C) 2015 Elsevier B.V. All rights reserved.
dc.identifier.citationMUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS,Vol.791,1-11,2015
dc.identifier.doi10.1016/j.mrgentox.2015.07.006
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3781
dc.language.isoen
dc.publisherELSEVIER SCIENCE BV
dc.sourceMUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
dc.subject.englishComet assay
dc.subject.englishDNA damage
dc.subject.englishHemocytes
dc.subject.englishMalondialdehyde
dc.subject.englishMitotic recombination
dc.subject.englishWing-spot test
dc.titleGenotoxicity of copper oxide nanoparticles in Drosophila melanogaster
dc.typeArticle
uct.catalogadorWOS
uct.indizacionSCI
Files
Collections
Migración Web of Science